The Parkinson’s Disease Composite Scale Is Adequately Responsive to Acute Levodopa Challenge

Table 4

Corresponding changes in the motor scores of the Parkinson’s Disease Composite Scale to the clinically relevant 20%, 24.5%, and 30% changes in the motor examination part of the MDS-UPDRS.

	PDCS improvement (%)	Sensitivity	Specificity	Youden’s index	+LR	−LR	AUC	ROC value
MDS-UPDRS 30% improvement	18.47	0.811	0.894	0.705	7.626	0.211	0.883	<0.001
MDS-UPDRS 24.5% improvement	16.59	0.857	0.863	0.720	6.245	0.166	0.885	<0.001
MDS-UPDRS 20% improvement	14.64	0.830	0.872	0.703	6.503	0.195	0.883	<0.001

The cutoff values were proposed as benchmarks based on [10, 22]. AUC = area under the curve; +LR = positive likelihood ratio; −LR = negative likelihood ratio; MDS-UPDRS = Movement Disorder Society-sponsored Unified Parkinson’s Disease Rating Scale; PDCS = Parkinson’s Disease Composite Scale; ROC = receiver operating characteristic.