Review Article

Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review

Table 2

Trials correlating PD and T2DM as a risk factor.

Risk of PD in patients with T2DMAuthorsSample

Increased (n = 9)De Pablo-Fernandez et al. [20]T2DM: 2,017,115
Controls: 6,173,208
De Pablo-Fernandez et al. [43]PD: 79 (14 with T2DM)
Controls: 4.919 (842 with T2DM)
Yang et al. [44]T2DM: 36.294 (550 with PD)
Controls: 108.882 (1232 with PD)
Yue et al. [45]PD: 6441
Controls: 1.755.191
Sun et al. [46]T2DM: 603.413 (1.613 with PD)
Controls: 472.718 (809 with PD)
Wahlqvist et al. [47]T2DM: 64.166
Controls: 698.587
Schernhammer [48]PD: 1.931 (126 with T2DM)
Controls: 9.651 (482 with T2DM)
Xu et al. [49]T2DM: 21.611 (172 with PD)
Controls: 267.051 (1393 with PD)
Hu et al. [19]T2DM: 1.098 (24 with PD)
Controls: 50.454 (609 with PD)

Decreased (n = 5)Miyake et al. [50]PD: 249 (10 with T2DM)
Controls: 368 (39 with T2DM)
D′ Amelio et al. [51]PD: 318 (13 with T2DM)
Controls: 318 (31 with T2DM)
Leibson et al. [52]PD: 197 (18 with T2DM)
Controls: 197 (24 with T2DM)
Powers et al. [53]PD: 352 (26 with T2DM)
Controls: 484 (61 with T2DM)
Herishanu et al. [54]PD: 93 (11 with T2DM)
Controls: 93 (26 with T2DM)

Not related (n = 4)Savica et al. [22]PD: 196 (13 with T2DM)
Controls: 196 (17 with T2DM)
Palacios et al. [55]PD: 656
Controls: 147,440
Driver et al. [56]PD: 556
Controls: 21.285
Simon et al. [57]PD: 530 (37 with T2DM)
Controls: 171.349 (3.722 with T2DM)

Risk of T2DM in patients with PD
Decreased (n = 2)Becker et al. [58]PD: 3.637 (291 with T2DM)
Controls: 3.637 (308 with T2DM)
Scigliano et al. [59]PD: 178 (6 with T2DM)
Controls: 534 (58 with T2DM)
Increased (n = 1)Pressley et al. [60]PD: 791 (235 with T2DM)
Controls: 24.040 (5.175 with T2DM)
Total = 21