Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review

Table 4

Trials correlating clinical features of patients with PD and T2DM.

Influence of T2DM on PD	Authors	PD with T2DM/PD without T2DM
Major cognitive impairment (n = 3)	Ong et al. [65]	PD with T2DM: 11; PD without T2DM: 51
	Petrou et al. [66]	PD with T2DM: 12; PD without T2DM: 24
	Bohnen et al. [67]	PD with T2DM: 15; PD without T2DM: 133
Worsening of motor symptoms and/or postural instability (n = 4)	Mohamed Ibrahim et al. [68]	PD with T2DM: 25; PD without T2DM: 25
	Pagano et al. [69]	PD with T2DM: 21; PD without T2DM: 51
	Kotagal et al. [70]	PD with T2DM: 13; PD without T2DM: 26
	Cereda et al. [71]	PD with T2DM: 466; PD without T2DM: 921
Influence of PD on T2DM
Reduction of glycemia and/or glycated hemoglobin and lipid profile improvement (n = 1)	Scheuing et al. [72]	PD with T2DM: 1579; PD without T2DM: 177.413