Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal Study

Table 2

Standardized, unadjusted progression rates (in % of maximum score per year or % of baseline score per year).

	Progression rate per year
	Over 1 year; n = 50; Mean % (SD)	Over 2 years; n = 55; Mean % (SD)	Over 5 years; n = 34; Mean % (SD)
CWT	6.6 (19.3)	2.9 (9.5)	0.4 (5.1)
6MWT	9.7 (21.8)	3.0 (12.4)	−0.5 (4.1)
Mini-BESTest	−1.2 (8.5)	−0.4 (4.8)	−1.1 (2.1)
UPDRS II	0.6 (7.3)	1.1 (4.2)	0.9 (2.3)
PDQ-39 summary index	−1.2 (6.8)	−0.7 (4.0)	0.4 (2.6)
	Median % (IQR)	Median % (IQR)	Median % (IQR)
H&Y score	0.0 (20.0)	0.0 (10.0)	0.0 (4.0)
ABC	0.0 (10.7)	−0.9 (7.1)	−1.1 (2.7)

% of baseline score per year. CWT = comfortable 10-meter walk test; 6MWT = six-minute walk test; Mini-BESTest = Mini-Balance Evaluations System Test; UPDRS = unified Parkinson’s disease rating scale; PDQ-39 = 39-item Parkinson’s disease questionnaire; H&Y = Hoehn and Yahr; ABC = activities-specific balance confidence scale. A negative percentage indicates a progression (decline) in scores for the following measures: CWT, 6MWT, Mini-BESTest, and ABC. A positive percentage indicates a progression (decline) in scores for the following measures: UPDRS II, PDQ-39, and H&Y (with the opposite sign indicating improvement of symptoms).