; ; ; †. aPredicted value on variable at baseline; bpredicted change in variable score per year; cstandardized intraindividual association between variable and ESS; dincluding all antiparkinsonian medications, derived according to Tomlinson et al. ; eincluding only levodopa (and associated enzyme inhibitors), derived according to Tomlinson et al. ; fincluding only dopamine agonists, derived according to Tomlinson et al. ; gas assessed during the “ON” phase; hhigh scores = more problems; ihigh scores = less problems; jfrom year 1. ESS, Epworth Sleepiness Scale; PD, Parkinson’s disease; UPDRS, Unified Parkinson’s Disease Rating Scale; FACIT-F, Functional Assessment of Chronic Illness Therapy-Fatigue scale; SD, standard deviation; HADS, Hospital Anxiety and Depression Scale; PSQI, Pittsburgh Sleep Quality Index profile; MADRS-S, Montgomery and Asberg Depression Rating Scale-Self.