Variants in the 3′ End of SLC6A3 in Northwest Han Population with Parkinson’s

Table 3

Frequency distribution of SLC6A3 genotypes and alleles.

Gene	Allele/genotype	PD (n)	Control (n)	χ^2		OR	95% CI
rs2270913	C	698 (1.000)	768 (1.000)
	C/C	349 (1.000)	384 (1.000)
rs27048	C	620 (0.912)	652 (0.867)	0.939	0.332	0.585	0.620–4.0483
	T	60 (0.088)	100 (0.133)
	C/C	280 (0.824)	276 (0.734)
	C/T	60 (0.176)	100 (0.266)	1.089	0.297	1.691	0.626–4.566
rs2270914	G	700 (1.000)	768 (1.000)
	G/G	350 (1.000)	384 (1.000)
rs2550936	A	651 (0.930)	712 (0.908)
	C	49 (0.070)	72 (0.092)	0.271	0.602	1.315	0.469–3.685
	A/A	301 (0.860)	320 (0.816)
	A/C	49 (0.140)	72 (0.184)	0.301	0.584	0.350	0.460–3.960
rs11133767	A	31 (0.043)	36 (0.046)
	G	669 (0.956)	748 (0.954)	0.011	0.914	0.930	0.245–3.539
	A/G	31 (0.089)	36 (0.092)
	G/G	319 (0.911)	356 (0.908)	0.012	0.914	0.927	0.236–3.640
rs3776510	C	668 (0.954)	744 (0.949)
	T	32 (0.046)	40 (0.051)	0.074	0.786	1.201	0.321–4.495
	C/C	318 (0.909)	352 (0.898)
	C/T	32 (0.091)	40 (0.102)	0.078	0.780	1.212	0.314–4.686
rs429699	C	500 (0.714)	592 (0.755)
	T	200 (0.286)	192 (0.245)	0.452	0.502	0.811	0.440–1.495
	C/C	190 (0.543)	220 (0.561)
	C/T	120 (0.343)	152 (0.388)
	T/T	40 (0.114)	20 (0.051)	1.679	0.43
rs11564759	C	403 (0.576)	443 (0.589)
	T	297 (0.424)	309 (0.411)	0.076	0.783	0.924	0.531–1.611
	C/C	131 (0.374)	116 (0.309)
	C/T	141 (0.403)	211 (0.561)
	T/T	78 (0.223)	49 (0.130)	3.303	0.192
rs27047	C	450 (0.643)	488 (0.622)
	T	250 (0.357)	296 (0.378)	0.092	0.762	1.092	0.619–1.926
	C/C	150 (0.429)	160 (0.408)
	C/T	150 (0.429)	168 (0.429)
	T/T	50 (0.143)	64 (0.163)	0.094	0.954
rs6347	A	641 (0.914)	771 (0.920)
	G	59 (0.086)	67 (0.080)	0.001	0.979	1.013	0.383–2.682
	A/A	291 (0.831)	325 (0.829)
	A/G	59 (0.169)	67 (0.171)	0.001	0.978	1.014	0.365–2.821
rs40184	A	210 (0.292)	112 (0.140)
	G	510 (0.708)	688 (0.860)	8.245	0.004	2.529	1.325–4.827
	A/A	20 (0.056)	8 (0.020)
	A/G	170 (0.472)	96 (0.240)
	G/G	170 (0.472)	296 (0.740)	8.760	0.013
rs37022	A	314 (0.431)	402 (0.502)
	T	406 (0.569)	398 (0.498)	1.337	0.246	0.726	0.422–1.250
	A/A	73 (0.194)	93 (0.232)
	A/T	168 (0.472)	216 (0.540)
	T/T	119 (0.333)	91 (0.228)	1.83	0.340
rs10036478	C	614 (0.853)	704 (0.880)
	T	106 (0.147)	96 (0.120)	0.507	0.476	0.756	0.3499–1.634
	C/C	262 (0.728)	309 (0.773)
	C/T	90 (0.250)	86 (0.215)
	T/T	8 (0.028)	5 (0.012)	0.753	0.686
rs2652514	C	577 (0.824)	693 (0.866)
	T	123 (0.176)	107 (0.134)	0.736	0.392	0.722	0.343–1.523
	C/C	238 (0.680)	299 (0.748)
	C/T	101 (0.289)	95 (0.238)
	T/T	11 (0.031)	6 (0.015)	0.965	0.617
rs2981359	C	383 (0.532)	388 (0.485)
	G	337 (0.468)	412 (0.515)	0.680	0.410	1.255	0.731–2.154
	C/C	96 (0.267)	104 (0.260)
	C/G	191 (0.530)	180 (0.450)
	G/G	73 (0.203)	116 (0.290)	1.285	0.526
rs365663	C	420 (0.583)	517 (0.646)
	T	300 (0.417)	283 (0.354)	0.862	0.353	0.771	0.444–1.337
	C/C	110 (0.306)	165 (0.412)
	C/T	200 (0.556)	187 (0.468)
	T/T	50 (0.139)	48 (0.120)	1.224	0.542
rs11133770	A	658 (0.914)	737 (0.921)
	C	62 (0.086)	63 (0.079)	0.052	0.820	0.892	0.332–2.395
	A/A	298 (0.828)	337 (0.843)
	A/C	62 (0.172)	63 (0.157)	0.056	0.812	0.882	0.314–2.482

OR = odds ratio; CI = confidence interval; χ² = Pearson chi-square. .