Research Article
Subthalamic Nucleus Stimulation Does Not Have Any Acute Effects on Verbal Fluency or on Speed of Word Generation in Parkinson’s Disease
Table 1
Demographic and clinical characteristics of the Parkinson’s disease patients, and the cognitive and mood measures Off and On STN-DBS.
| | | Off | On | value |
| | Demographic | | Number of participants (F/M) | 31 (10/21) | — | — | | Years of education | 14.1 (3.2) | — | — | | Age | 58.8 (6.9) | — | — | | Handedness (L/R) | 5/26 | — | — |
| | Clinical | | Disease duration (years) | 14.7 (4.7) | — | — | | UPDRS-III | 29.8 (17.1) | 11.7 (8.1) | 0.0001 | | STN-DBS voltage—L | — | 2.7 (0.8) | — | | STN-DBS voltage—R | — | 2.9 (0.7) | — | | STN-DBS frequency—L | — | 136 (13.8) | — | | STN-DBS frequency—R | — | 133.3 (9.9) | — | | STN-DBS pulse—L | — | 62.13 (7.7) | — | | STN-DBS pulse—R | — | 61.10 (5.6) | — |
| | Cognition | | Trail making test (time—part A) | 47.3 (20.6) | 41.2 (27.5) | 0.06 | | Trail making test (time—part B) | 120.1 (107.9) | 115.1 (105.9) | 1 | | Trail making test (time difference parts B and A) | 72.8 (92.7) | 72.8 (80.6) | 0.51 | | Stroop (interference, time) | 69.2 (50.5) | 67.4 (59.9) | 0.42 | | Stroop (interference, errors) | 2.5 (3) | 2.4 (3.7) | 0.78 |
| | Mood and behaviour | | HADS—anxiety | 5.8 (3.4) | 5.2 (3) | 0.54 | | HADS—depression | 4.9 (2.4) | 5.1 (2.9) | 0.92 | | Apathy | 10.5 (5.5) | 12.6 (7.9) | 0.32 |
| | Fatigue | | Physical | 6.1 (3.2) | 4.1 (2.9) | 0.03 | | Mental | 6.4 (2.5) | 5.1 (2.3) | 0.10 |
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Results are given as mean ± SD (Kruskal–Wallis test). F: female; HADS: Hospital Anxiety and Depression Scale; L: left; M: male; PD: Parkinson’s disease; R: right; STN-DBS: Subthalamic deep brain stimulation; UPDRS: Unified Parkinson’s Disease Rating Scale.
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