7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents

Figure 4

Effect of 7,8-DHF on the peripheral organs of the rotenone-induced PD animal model. Pathological changes in peripheral organs of rats exposed to rotenone, based on H&E staining, presented alveolar ectasia and alveolar wall fragmentation in the lung and hepatic sinus expansion around the central tube in the liver. No associated peripheral organs toxicity was observed in the heart, kidney, and spleen.