Research Article
LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan
Table 1
Clinical and demographic characteristics of the cohort.
| | Cases | Controls |
| Number | 246 | 200 |
| Ethnic groups, abs number (%) | Kazakhs 179 (72.8%) | | Russians 51 (20.7%) | Uygurs 7 (2.8%) | Tatars 5 (2%) | Koreans 3 (1.3%) | Tajiks 1 (0.4%) |
| Sex distribution | Males—120, females—126 M : F ratio−0.95 : 1 | Males—62, females—138 M : F ratio 0.4 : 1 |
| Age at examination (mean) | 61.7 ± 10.3 (range 28–83) For males—60.3 ± 10.6 (range 28–82), For females—63.1 ± 9.9 (range—32–83) | Mean age—54.93 ± 4.8 (47–66) For males—55.27 ± 4.8 (47–66) For females—54.78 ± 4.7 (47–65) |
| Age of onset (mean) | 55.06 ± 11.15 (range 14–77) For males—53.3 ± 11.9 (range 14–76), For females—56.8 ± 9.9 (range 26–77) | |
| Disease duration (mean) | 13.2 ± 9.3 (range 1–24) | |
| HY stage off (mean) | 2.4 ± 0.6 (range 1–5) For males—2.3 ± 0.7 For females—2.4 ± 0.6 | |
| Family history of PD and tremor, abs number (%) | 21 (8.5%) | |
| Young-onset cases, abs number (%) | 31 (12.6%) before the age of 40 65 (26.4%) before the age of 50 | |
|
|
M : F–male to female.
|