Research Article
LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan
Table 1
Clinical and demographic characteristics of the cohort.
| | | Cases | Controls |
| | Number | 246 | 200 |
| | Ethnic groups, abs number (%) | Kazakhs 179 (72.8%) | | | Russians 51 (20.7%) | | Uygurs 7 (2.8%) | | Tatars 5 (2%) | | Koreans 3 (1.3%) | | Tajiks 1 (0.4%) |
| | Sex distribution | Males—120, females—126
M : F ratio−0.95 : 1 | Males—62, females—138
M : F ratio 0.4 : 1 |
| | Age at examination (mean) | 61.7 ± 10.3 (range 28–83)
For males—60.3 ± 10.6 (range 28–82),
For females—63.1 ± 9.9 (range—32–83) | Mean age—54.93 ± 4.8 (47–66)
For males—55.27 ± 4.8 (47–66)
For females—54.78 ± 4.7 (47–65) |
| | Age of onset (mean) | 55.06 ± 11.15 (range 14–77)
For males—53.3 ± 11.9 (range 14–76),
For females—56.8 ± 9.9 (range 26–77) | |
| | Disease duration (mean) | 13.2 ± 9.3 (range 1–24) | |
| | HY stage off (mean) | 2.4 ± 0.6 (range 1–5)
For males—2.3 ± 0.7
For females—2.4 ± 0.6 | |
| | Family history of PD and tremor, abs number (%) | 21 (8.5%) | |
| | Young-onset cases, abs number (%) | 31 (12.6%) before the age of 40
65 (26.4%) before the age of 50 | |
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M : F–male to female.
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