LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan

Table 4

The allelic frequency and odds ratios for the positive LRRK2 Asian disease-associated variants.

SNP	Nucleotide change	Amino acid change	MAF		Or (95% CI)	value
			PD (n = 239^a, 242^b, 236^c)	Controls (n = 199)
rs34778348	c.7153G>A	p.Gly2385Arg^a	0.007 (A)	0.005 (A)	1.25 (0.2071–7.5688)	0.8
rs34594498	c.1256C>T	p.Ala419Val^b	0.02 (T)	0.012 (T)	1.5 (0.4941 – 4.5463)	0.4
rs33949390	c.4883G>C	p.Arg1628Pro^c	0.0 (C)	0.005 (C)	NA	NA

MAF–minor allele frequency, NA–not applicable, OR–odds ratio, and PD–Parkinson’s disease.