LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan

Table 7

Studies investigating LRRK2 p.Ala419Val variant in Asian populations.

	Cases	Controls	Ethnicity	OR	MAF for patients/controls
Di Fonzo et al., 2006 [6]	582/10	341/3	Han Chinese from Taiwan	1.95 (0.53–7.15),	0.008/0.004
Nuytemans et al., 2009 [27]	620/1	540/0	Belgian
Jasinska-Myga, 2010 [12]	165/0	364/0	Arab-Berber ethnicity	n/a
Tan et al., 2010 [28]	250/0	250/0	Han Chinese	n/a
Ross et al., 2011 [23]	1,376	962	Japan, Korea, Taiwan	OR: 2.27, 95% CI: 1.35–3.83,
	Japan PD: 173	Control: 75		Japan: OR 1.26 (0.38 to 4.22)
	Korea PD: 844	Control: 587		Korea: OR 2.21 (1.2 to 4.06)
	Taiwan PD: 369	Control: 300		Taiwan: OR 7.51 (0.95 to 59.6)
Li et al., 2012 [29]	729/22	585/4	Han Chinese	OR, 4.14; 95% CI: 1.53–12.74	0.015
Wu et al., 2012 [30]	1517/13	1487/13	Han Chinese from China and Singapore Taiwanese	0.98 (0.45 to 2.18)	0.004
Gopalai et al., 2013 [31]	404/1	424/3	Chinese (223/236), Malay (122/110), and Indian (59/78)	0.35, 95% CI: 0.01 to 3.79;	0.002 cases; 0.004 Controls
Heckman et al., 2013 [32]	369/10	300/1	Taiwan, South Korea, Japan	OR 8.33 (1.06–65.43)	Taiwanese 0.013; Japanese – 0.026; South Korea 0.029
Wu-Chou et al., 2013 [33]	626/0	473/0	Han Chinese from Taiwan	n/a
Li et al., 2015 [26]	500/18	574/9	Chinese	OR 2.57, 95% CI: 1.13–5.86,	0.018

OR–odds ratio and MAF–minor allele frequency.