Review Article

Role of Long Noncoding RNAs in Parkinson’s Disease: Putative Biomarkers and Therapeutic Targets

Table 2

Altered lncRNAs in Parkinson’ Disease.

TissueEthnicity/populationLncRNARegulationReferences

Substantia nigra and cerebellum (9 patients with PD and 8 controls)Not mentioned (the tissue were obtained from The Netherlands brain Bank)AK127687, AX747125, GBAP1, SNCA-AS1, UCHL1-AS1, PINK1-AS1, and MAPT-AS1Up[47]
Anterior cingulate gyrus (20 patients with PD and 10 controls)Not mentioned (the tissue were provided by the Neurobiobank Munich (NBM))H19 upstream conserved 1 and 2Up[48]
LincRNA-p21, MALAT1, SNHG1, and TncRNADown
Exosomes isolated from CSF (47 patients with PD and 27 controls)Not mentioned (the tissue were provided by the sir Run Run shaw hospital, affiliated with school of medicine, Zhejiang University)RP11-462G22.1 and PCA3Up[49]
Extracellular RNAs present in CSF (27 patients with PD and 30 controls)Not mentioned (the tissue were provided by the hospital Universitario Donostia, San Sebastian, Spain (MDUD))AC079630 and UC001lva.4 (close to the LRRK2 gene locus)Up[50]
Substantia nigra (11 patients with PD and 14 controls)Not mentioned (the volunteers who provided the tissue were from USA, UK, Israel, and Germany)AL049437, U79277, AF052141, AK021454, BC018626, AF147723, AK001884, AY365119, BC151247, BC151234, AK311445, AK310272, AK094351, AF007131, AF119861, CR619166, AK023852, AK074162, AF052176, BC007937, AK025388, AK022431, CR618512, AK021912, AL109681, AF090884, AL359578, AF070543, AK021798, AK024568, U94902, AK024381, AF090910, BC002644, BC064478, AF007141, M28219, AK001998, BC002821, AL049328, AK024684, and AK000420Up[51]
AK024198, AK025097, AK024214, AF052148, AF070579, AK023918, AK022167, AK024938, AL109707, BC000988, AK025271, AL109705, AJ001873, BC029383, AK025360,Down
Blood leukocytes sample (3 patients with PD)Not mentionedRP11-101C11.1, U1‘#, RP11-425i13.3, RP11-124n14.3, RP11-79p5.3, RP11-462g22.1, RP13-507P19.2, and PCA3Up[20]
RP11-409K20.6, RP4-705O1.1, AC004744.3, RP11-533O20.2, and RP11-542K23.9Down
Brain tissue samples (10 patients with PD and 10 controls)Caucasian descent (the tissue were provided by the Sydney Brain Bank and the NSW Tissue Resource Centre)MAPT-AS1Down[35]
Plasma samples (32 patients with PD and 13 controls)Not mentioned (the volunteers who provided the tissue were from Beijing Tiantan Hospital)MSTRG.242001.1, MSTRG.169261.1Up[52]
MSTRG.336210.1, lnc-MKRN2-42 : 1Down
Substantia nigra from mice (3 Nrf2+/+ mice and 3 Nrf2-/- mice)AK020441, AK020330, NR_003555, NR_073442, AK040987, ENSMUST00000142871, ENSMUST00000153819, ENSMUST00000132304, uc011ysu.1, and so forth (a total of 74)Up[53]
ENSMUST00000139383, NR_024325, AK047372, ENSMUST00000156693, ENSMUST00000181307, AK076880, AK036620, TCONS_00017218, TCONS_00022981, TCONS_00004085, and so forth (a total of 160)Down
Whole mesencephalic tissues from mice (6 α-synuclein transgenic C57BL/6 mice and 6 control mice)uc.44-, BC037523, and so forth (a total of 164)Up[54]
uc.12+, AK076860, and so forth (a total of 177)Down
The striatum from rat (9 PD model and 9 control rats)XLOC_026924, XLOC_029397, XLOC_004631, XLOC_005439, XLOC_018657, XLOC_016191, XLOC_022926, AABR07029901.1, XLOC_025867, XLOC_016202, and so forth (a total of 451)Up[55]
XLOC_028318, XLOC_037769, XLOC_029657, XLOC_010572, XLOC_017775, XLOC_018598, Rn50_5_1638.1, XLOC_006399, AABR07027137.1, XLOC_001547, and so forth (a total of 61)Down
SY-SH5Y cells treated with a-synuclein oligomersA total of 53 lncRNAsUp[56]
A total of 69 lncRNAsDown
Whole mesencephalic tissues from mice (6 α-synuclein transgenic C57BL/6 mice and 6 control mice)uc.44-, BC037523, and so forth (a total of 164)Up[5]
uc.12+, AK076860, and so forth (a total of 177)Down