Research Article
Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease
Table 3
Secondary outcome comparisons between active and sham rTMS groups.
| | UPDRS part III | UPDRS | NMSQ | HRSD | PSQI | MoCA |
| Active | T0 | 27.84 (8.96) | 48.58 (15.90) | 12.05 (4.61) | 13.26 (6.90) | 9.63 (4.87) | 24.37 (3.53) | T1 | 21.95 (7.99)ab | 39.32 (12.50)ab | 9.53 (4.14)ab | 8.79 (5.19)ab | 7.63 (4.42)b | 26.37 (2.67)ab | T2 | 22.26 (7.32)ab | 39.47 (11.44)ab | 10.37 (4.18)ab | 10.32 (5.33)ab | 7.11 (3.91)ab | 26.58 (3.67)ab | T3 | 25.68 (8.58)ab | 43.05 (14.82) | 11.05 (4.4)3b | 12.32 (6.47)a | 7.3 (3.89)ab | 26.58 (3.04)ab | T4 | 27.00 (9.46) | 44.26 (14.81) | 11.53 (4.41) | 12.74 (6.99) | 8.00 (4.11) | 26.47 (3.17)ab |
| Sham | T0 | 29.00 (13.16) | 43.71 (19.13) | 8.79 (5.16) | 15.86 (7.12) | 7.57 (3.25) | 22.57 (3.13) | T1 | 28.64 (12.57) | 43.43 (18.47) | 8.57 (5.69) | 15.50 (6.78) | 7.50 (3.06) | 22.93 (2.92) | T2 | 28.64 (13.84) | 43.43 (19.86) | 8.43 (5.46) | 15.57 (7.23) | 7.57 (3.13) | 22.71 (2.97) | T3 | 28.79 (13.43) | 43.71 (21.36) | 9.86 (5.33) | 15.36 (6.92) | 8.36 (3.95) | 22.29 (2.87) | T4 | 28.79 (13.11) | 43.57 (21.18) | 9.93 (5.26) | 15.36 (7.22) | 8.43 (3.84) | 22.14 (2.91) |
| | 14.215 | 3.153 | 3.461 | 13.916 | 5.052 | 9.192 | | | <0.001 | 0.057 | 0.038 | <0.001 | 0.006 | <0.001 | |
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Abbreviations: H-Y stage: Hoehn and Yahr stage; LED: levodopa equivalent dose; UPDRS: Unified Parkinson’s Disease Rating Scale; NMSQ: Nonmotor Symptom Questionnaire; HRSD: Hamilton Rating Scale for Depression; PSQI: Pittsburgh Sleep Quality Index; MoCA: Montreal Cognitive Assessment. T0: baseline; T1: after treatment; T2: 1 month; T3: 3 months; T4: 6 months. and values for rANOVA interaction (time and group) with adjustment for nonsphericity. aSignificant difference from baseline. bSignificant difference between groups. |