Phosphorylated Alpha-Synuclein in Red Blood Cells as a Potential Diagnostic Biomarker for Multiple System Atrophy: A Pilot Study

Table 6

pS-α-syn-RBC levels of the study subjects.

pS-α-syn levels in RBCs	MSA-total (n = 75)	MSA-P (n = 33)	MSA-C (n = 42)	values
All	12.67 ± 2.64	13.27 ± 1.91	12.19 ± 3.04	0.025^a
pS-α-syn-RBC levels in patients stratified by age at onset, ng/mg
<50	12.75 ± 2.80	13.30 ± 1.88	12.53 ± 3.15	0.658
≥50	12.64 ± 2.63	13.27 ± 1.94	12.08 ± 3.04	0.050^a
50–59	12.70 ± 3.00	12.99 ± 2.20	12.46 ± 3.58	0.645
60–69	12.15 ± 2.44	13.47 ± 1.80	11.04 ± 2.40	0.016
≥70	13.59 ± 1.61 ( for trend: 0.564)	13.53 ± 1.85 ( for trend: 0.926)	13.68 ± 1.46 ( for trend: 0.416)	0.897
pS-α-syn-RBC levels in patients stratified by disease duration, ng/mg
0–2	12.41 ± 2.43	13.11 ± 1.65	11.86 ± 2.81	0.111
3–5	12.68 ± 2.70	13.17 ± 2.14	12.25 ± 3.12	0.406
>5	13.90 ± 3.39 ( for trend: 0.474)	14.63 ± 2.47 ( for trend: 0.528)	13.46 ± 4.05 ( for trend: 0.609)	0.670
pS-α-syn-RBC levels in patients stratified by H&Y stages, ng/mg
1–2	11.41 ± 1.72	12.66 ± 0.35	10.57 ± 1.79	0.217
3	12.85 ± 2.75	12.92 ± 1.96	12.79 ± 3.31	0.649^a
4	12.04 ± 2.42	13.16 ± 1.70	11.38 ± 2.60	0.125
5	14.09 ± 2.69 ( for trend: 0.215)	15.49 ± 1.10 ( for trend: 0.092)	12.23 ± 3.28 ( for trend: 0.539)	0.116

^aMann–Whitney U test.