Altered Regional Homogeneity and Functional Connectivity during Microlesion Period after Deep Brain Stimulation in Parkinson’s Disease
Table 2
Regions with ReHo differences between the pre-PD group and HCs, as well as between the pre-PD group and the post-PD group (voxel , FWE correction with cluster ).
Brain region (AAL)
Voxel size
MNI coordinate
Peak T-value
X
Y
Z
Pre-PD>HC
Cluster1
Frontal_Sup_Orb_R
47
15
39
−30
4.6419
HC>pre-PD
Cluster1
Frontal_Mid_R
39
45
42
15
−5.9629
Cluster2
Temporal_Mid_R
75
60
−54
12
−4.7052
Cluster3
Occipital_Sup_R
51
24
−87
18
−5.5474
Cluster4
Occipital_Mid_R
47
33
−60
27
−4.325
Cluster5
Angular_R
62
27
−66
42
−5.0054
Pre-PD>post-PD
Cluster1
Cerebellum_Crus1/2_L
65
−39
−45
−45
4.8602
Cluster2
Temporal_Mid_L/angular_L
48
−60
−60
15
11.8391
Cluster3
Precuneus_R/L
88
0
−60
42
4.9435
Cluster4
Frontal_Mid_L
167
−27
24
51
7.2589
Cluster5
Frontal_Mid_R
62
39
30
54
5.6951
Post-PD>pre-PD
Cluster1
Frontal_Inf_Orb_R
35
24
18
−21
−5.3848
Cluster2
Supp_Motor_Area_L/cingulum_Mid_L
51
−9
−9
45
−7.0682
Cluster3
Paracentral_Lobule_R/L
59
−3
−15
78
−5.5623
HCs, healthy controls; PD, Parkinson’s disease; ReHo, regional homogeneity; FWE, the family-wise error; pre-PD, before DBS; post-PD, one day after DBS; AAL, anatomical automatic labeling; MNI, Montreal Neurological Institute; DBS, deep brain stimulation.