Altered Regional Homogeneity and Functional Connectivity during Microlesion Period after Deep Brain Stimulation in Parkinson’s Disease

Table 2

Regions with ReHo differences between the pre-PD group and HCs, as well as between the pre-PD group and the post-PD group (voxel , FWE correction with cluster ).

	Brain region (AAL)	Voxel size	MNI coordinate			Peak T-value
			X	Y	Z
Pre-PD > HC
Cluster1	Frontal_Sup_Orb_R	47	15	39	−30	4.6419
HC > pre-PD
Cluster1	Frontal_Mid_R	39	45	42	15	−5.9629
Cluster2	Temporal_Mid_R	75	60	−54	12	−4.7052
Cluster3	Occipital_Sup_R	51	24	−87	18	−5.5474
Cluster4	Occipital_Mid_R	47	33	−60	27	−4.325
Cluster5	Angular_R	62	27	−66	42	−5.0054
Pre-PD > post-PD
Cluster1	Cerebellum_Crus1/2_L	65	−39	−45	−45	4.8602
Cluster2	Temporal_Mid_L/angular_L	48	−60	−60	15	11.8391
Cluster3	Precuneus_R/L	88	0	−60	42	4.9435
Cluster4	Frontal_Mid_L	167	−27	24	51	7.2589
Cluster5	Frontal_Mid_R	62	39	30	54	5.6951
Post-PD > pre-PD
Cluster1	Frontal_Inf_Orb_R	35	24	18	−21	−5.3848
Cluster2	Supp_Motor_Area_L/cingulum_Mid_L	51	−9	−9	45	−7.0682
Cluster3	Paracentral_Lobule_R/L	59	−3	−15	78	−5.5623

HCs, healthy controls; PD, Parkinson’s disease; ReHo, regional homogeneity; FWE, the family-wise error; pre-PD, before DBS; post-PD, one day after DBS; AAL, anatomical automatic labeling; MNI, Montreal Neurological Institute; DBS, deep brain stimulation.