Altered Regional Homogeneity and Functional Connectivity during Microlesion Period after Deep Brain Stimulation in Parkinson’s Disease

Table 3

Regions showing altered functional connectivities between the pre-PD group and the post-PD group (voxel , FWE correction with cluster ).

Seed area	Brain region (AAL)	Cluster size	Peak MNI coordinate			Peak T-value
Pre-PD > Post-PD
Left posterior cerebellar lobe as the seed
Cluster 1	Cerebellum_8_L	196	−33	−48	−42	6.0512
	Cerebellum_Crus1_L
Left middle temporal gyrus as the seed
	Temporal_Mid_L	147	−60	−63	12	7.6778
Bilateral precuneus as the seed
Cluster 1	Angular_L	198	−57	−60	30	7.0958
Cluster 2	Precuneus_L	93	−6	−57	36	5.4209
Cluster 3	Frontal_Sup_L	151	−21	36	48	6.239
Left middle frontal gyrus as the seed
Cluster 1	Frontal_Sup_Medial_L	124	0	54	9	5.19
Cluster 2	Frontal_Mid_L	73	−45	30	33	4.8853
Cluster 3	Angular_L	302	−39	−63	48	7.1131
Cluster 4	Precuneus_L	214	−3	−66	45	6.8136
Cluster 5	Angular_R	236	45	−69	42	7.6871
Cluster 6	Frontal_Sup_Medial_R	201	−3	42	45	7.0057
Right middle frontal gyrus as the seed
Cluster 1	Angular_R	221	51	−66	39	6.8844
Cluster 2	Frontal_Sup_Medial_R	140	18	45	42	5.054
Post-PD > Pre-PD
Bilateral precuneus as the seed
Cluster 1	Supp_Motor_Area_R	48	3	18	45	−5.0847
Cluster 2	SupraMarginal_R	53	60	−36	48	−5.1899
Left middle frontal gyrus as the seed
Cluster 1	Cerebellum_8_L	141	−18	−78	−45	−5.5137
Cluster 2	Cerebellum_8_R	78	15	−78	−45	−4.9594
Cluster 3	Lingual_R	265	18	−63	−6	−7.4628
Cluster 3	Lingual_L	138	−18	−63	−6	−7.1345
Cluster 5	SupraMarginal_L	116	−54	−30	30	−5.4536
Right middle frontal gyrus as the seed
Cluster 1	Frontal_Inf_Tri_L	52	−39	33	−3	−4.8022
	Frontal_Inf_Orb_L
Cluster 2	SupraMarginal_L	45	−63	−33	30	−4.6723
Bilateral paracentral lobule as the seed
Cluster 1	Cingulum_Mid_R	47	0	−33	42	−5.0405

Pre-PD, before DBS; post-PD, one day after DBS; AAL, anatomical automatic labeling; MNI, Montreal Neurological Institute; PD, Parkinson’s disease; DBS, deep brain stimulation; FWE, the family-wise error.