Characterizing Advanced Parkinson’s Disease: Romanian Subanalysis from the OBSERVE-PD Study

Table 1

APD indicators developed by Delphi method.

APD indicator	Measurement for fulfillment
(1) Troublesome motor fluctuations	Moderate or severe
(2) “Off” time	≥2 hours/waking day
(3) Nighttime sleep disturbances	Moderate or severe
(4) Troublesome dyskinesia	≥2 hours/waking day
(5) Nonmotor symptoms	Presence of fluctuations
(6) “Off” time	At least every 3 hours
(7) Levodopa dosing	≥5 times daily
(8) Activities of daily living limitation	Moderate or severe
(9) Falling	Most of/all of the time
(10) Dementia	Moderate or severe
(11) Psychosis	Moderate or severe

APD: advanced Parkinson’s disease.