Research Article
Characterizing Advanced Parkinson’s Disease: Romanian Subanalysis from the OBSERVE-PD Study
Table 2
Demographics and disease-related characteristics.
| | Variable | APD (n = 95) | Non-APD (n = 66) | |
| | Mean age, years (SD) | 67.0 (8.3) | 65.5 (10.0) | 0.31 | | Males, n (%) | 57 (60) | 30 (45.5) | 0.097 | | Requirement of caregiver support (yes), n (%) | 82 (86.3) | 31 (47) | <0.0001 | | Mean time since diagnosis, years (SD) | 9.5 (5.1) | 3.7 (3.7) | <0.0001 | | Motor fluctuations (yes), n (%) | 88 (92.6) | 7 (7.4) | <0.0001 | | Mean time with motor fluctuations, years (SD) | 3.6 (2.9) | 2.9 (3.1) | 0.48 | | Comorbidities (yes), n (%) | 87 (91.6) | 62 (93.9) | 0.76 | | Cognitive dysfunction (yes), n (%) | 44 (46.3) | 13 (19.7) | <0.001 | | Mild | 33 (75) | 11 (84.6) | | | Moderate | 8 (18.2) | 2 (15.4) | | | Severe | 3 (6.8) | 0 | | | Hoehn andYahr stage, n (%) | | | <0.0001 | | Stage 1 | 0 (0) | 5 (7.6) | | | Stage 1.5 | 0 (0) | 8 (12.1) | | | Stage 2 | 0 (0) | 20 (12.1) | | | Stage 2.5 | 4 (4.2) | 22 (33.3) | | | Stage 3 | 55 (57.9) | 8 (12.1) | | | Stage 4 | 33 (34.7) | 3 (4.5) | | | Stage 5 | 3 (3.2) | 0 (0) | |
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APD: advanced Parkinson’s disease; SD: standard deviation. Statistically significant values (0.05) are presented in bold. |
