Characterizing Advanced Parkinson’s Disease: Romanian Subanalysis from the OBSERVE-PD Study

Table 6

Level of agreement between clinical judgement of APD diagnosis and fulfillment of each APD indicator.

Diagnosis	Number of patients (%)	APD indicator	Fulfillment of each APD indicator		Level of agreement
			Yes, n (%)	No, n (%)	Cohen’s Kappa	[95% CI]
APD	95 (59)	Moderate or severe troublesome motor fluctuations	62 (65.3)	33 (34.7)	0.555	[0.437−0.673]
Non-APD	66 (41)		4 (6.1)	62 (93.9)
APD	95 (59)	≥2 hours of the waking day with “off” symptoms	57 (60.0)	38 (40.0)	0.487	[0.366−0.608]
Non-APD	66 (41)		5 (7.6)	61 (92.4)
APD	95 (59)	Moderate or severe nighttime sleep disturbances	51 (53.7)	44 (46.3)	0.304	[0.168−0.439]
Non-APD	66 (41)		14 (21.2)	52 (78.8)
APD	95 (59)	≥2 hours of the day with troublesome dyskinesia	40 (42.1)	55 (57.9)	0.333	[0.222−0.444]
Non-APD	66 (41)		3 (4.6)	62 (95.4)
APD	95 (59)	Presence of nonmotor fluctuations	74 (77.9)	21 (22.1)	0.571	[0.444−0.698]
Non-APD	66 (41)		13 (19.7)	53 (80.3)
APD	95 (59)	Presence of “off” time at least every 3 hours	42 (44.2)	53 (55.8)	0.343	[0.228−0.457]
Non-APD	66 (41)		4 (6.1)	62 (93.9)
APD	95 (59)	≥5 times daily oral levodopa dosing	36 (37.9)	59 (62.1)	0.257	[0.143−0.370]
Non-APD	66 (41)		6 (9.1)	60 (90.9)
APD	95 (59)	Moderate or severe limitation of ADL capacity	77 (81.1)	18 (18.9)	0.593	[0.467−0.719]
Non-APD	66 (41)		14 (21.2)	52 (78.8)
APD	95 (59)	With falls most/all the time	14 (14.7)	81 (85.3)	0.124	[0.059−0.189]
Non-APD	66 (41)		0 (0.0)	66 (100.0)

ADL: activities of daily living; APD: advanced Parkinson’s disease; and CI: confidence interval. Cohen’s Kappa values > 0.5 are presented in bold.