Characterizing Advanced Parkinson’s Disease: Romanian Subanalysis from the OBSERVE-PD Study

Table 7

Presence of APD indicators in the APD patient population.

Delphi indicator	Yes, n (%)	No, n (%)
Moderate or severe troublesome motor symptoms fluctuations	62 (65.3)	33 (34.7)	<0.01
≥2 hours of the waking day with “off” symptoms	57 (60.0)	38 (40.0)	0.065
Moderate or severe night sleep disturbances	51 (53.7)	44 (46.3)	0.54
≥2 hours of the day with troublesome dyskinesia	40 (42.1)	55 (57.9)	0.15
Presence of NMS fluctuations	74 (77.9)	21 (22.1)	<0.0001
Presence of “off” time at least every 3 hours	42 (44.2)	53 (55.8)	0.3
≥5 times oral levodopa dosing	36 (37.9)	59 (62.1)	0.024
Moderate or severe limitation of ADL capacity	77 (81.1)	18 (18.9)	<0.0001
Falls most of/all of the time	14 (14.7)	81 (85.3)	<0.0001
Moderate or severe dementia	12 (12.6)	83 (87.4)	<0.0001
Moderate or severe psychosis	6 (6.3)	89 (93.7)	<0.0001

ADL: activities of daily living; APD: advanced Parkinson’s disease; and NMSs: nonmotor symptoms. Statistically significant values (0.05) are presented in bold.