Research Article
Characterizing Advanced Parkinson’s Disease: Romanian Subanalysis from the OBSERVE-PD Study
Table 7
Presence of APD indicators in the APD patient population.
| Delphi indicator | Yes, n (%) | No, n (%) | |
| Moderate or severe troublesome motor symptoms fluctuations | 62 (65.3) | 33 (34.7) | <0.01 | ≥2 hours of the waking day with “off” symptoms | 57 (60.0) | 38 (40.0) | 0.065 | Moderate or severe night sleep disturbances | 51 (53.7) | 44 (46.3) | 0.54 | ≥2 hours of the day with troublesome dyskinesia | 40 (42.1) | 55 (57.9) | 0.15 | Presence of NMS fluctuations | 74 (77.9) | 21 (22.1) | <0.0001 | Presence of “off” time at least every 3 hours | 42 (44.2) | 53 (55.8) | 0.3 | ≥5 times oral levodopa dosing | 36 (37.9) | 59 (62.1) | 0.024 | Moderate or severe limitation of ADL capacity | 77 (81.1) | 18 (18.9) | <0.0001 | Falls most of/all of the time | 14 (14.7) | 81 (85.3) | <0.0001 | Moderate or severe dementia | 12 (12.6) | 83 (87.4) | <0.0001 | Moderate or severe psychosis | 6 (6.3) | 89 (93.7) | <0.0001 |
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ADL: activities of daily living; APD: advanced Parkinson’s disease; and NMSs: nonmotor symptoms. Statistically significant values (0.05) are presented in bold. |