|
| | Participants | Type of study | Cognitive measure | Findings |
|
| Alcalay et al. [64] | 37 GBA-EOPD (≤50 years) | Cross-sectional | Self-reported cognitive impairment | GBA-PD reported more self-cognitive impairment compared with LRRK2-PD, Parkin-PD, and IPD |
| 596 EOPD (LRRK2-PD, Parkin-PD, and noncarrier PD) | MMSE | There were no significant differences among the genetic groups in MMSE |
| Brockmann et al. [79] | 20 GBA-PD | Cross-sectional | MoCA | GBA-PD performed worse than IPD |
| 20 IPD |
| Alcalay et al. [82] | 33 GBA-PD (≤50 years) | Cross-sectional | MMSE | GBA-PD performed worse on the MMSE, memory, and visuospatial domains |
| 60 EOPD noncarriers of any genetic mutation | Neuropsychological battery | Clinical diagnosis of MCI or dementia more frequent in GBA-PD |
| CORE-PD cohort | Clinical diagnosis (normal, MCI, dementia) |
| Mc Neil et al. [88] | 30 Gaucher’s disease patients | Cross-sectional | MMSE | Gaucher’s disease patients and GBA-PD performed worse in MoCA compared with controls; no significant differences in MMSE score |
| 30 GBA-PD | MoCA |
| 30 controls |
| Chanine et al. [83] | 20 GBA-PD | Cross-sectional | Consensus clinical determination | GBA-PD more likely to have MCI or dementia |
| 242 IPD |
| Setó-Salvia et al. [85] | 22 GBA-PD | Cross-sectional | Diagnosis of dementia based on a score ≥1 on the CDR and criteria of the MDS IV-TR | Higher prevalence of dementia in GBA-PD than in noncarriers |
| 225 IPD |
| Winder-Rhodes et al. [89] | 9 GBA-PD vs 250 non-GBA-PD (cross-sectional phase) | Cross-sectional and longitudinal | MMSE | No significant differences in MMSE comparing GBA-PD and noncarriers |
| 4 GBA-PD vs 106 noncarrier PD (longitudinal phase) | Diagnosis of dementia | GBA carriers had an increased risk of conversion to dementia (RR 5.45) |
| Mata et al. [90] | 60 GBA mutation carrier PD | Cross-sectional | Neuropsychological battery | GBA-PD and p.E326 K performed worse in working memory/executive function and visuospatial function; also, more proportion of dementia in both groups |
| 65 p.E326K polymorphism carriers |
| 1055 IPD |
| Davis et al. [91] | 27 GBA mutation carrier PD | Prospective longitudinal | Neuropsychological battery | p.E326 K PD had a higher proportion of progression to MCI and dementia |
| 32 p.E326K polymorphism carriers | Progression to MCI and dementia |
| 674 IPD |
| Malek et al. [92] | 142 GBA-PD | Cross-sectional | MoCA | No significant differences |
| 1584 IPD |
| Newly diagnosed PD patients (average disease duration 1.5 years) |
| Biswas et al. [93] | 198 IPD | Cross-sectional | Neuropsychological battery | Impaired recent memory was significantly associated with p.L444P carriers |
| 136 PD with cognitive impairment |
| 184 Parkinson plus 46 Alzheimer disease |
| 241 controls |
|
