Off Time Independently Affects Quality of Life in Advanced Parkinson’s Disease (APD) Patients but Not in Non-APD Patients: Results from the Self-Reported Japanese Quality-of-Life Survey of Parkinson’s Disease (JAQPAD) Study

Table 3

Summary of NMSQ scores.

	Patients, mean (SD)		value
	Non-APD	APD
Item
Digestive disorder	2.6 (1.6)	3.4 (1.7)	<0.0001
Urinary disorder	1.5 (0.7)	1.6 (0.6)	<0.0001
Memory disorder	1.8 (1.0)	2.1 (1.0)	<0.0001
Autonomic dysfunction	0.9 (0.7)	1.1 (0.7)	<0.0001
Sleep disorder	2.3 (1.4)	2.9 (1.4)	<0.0001
Perceptual disorder	0.6 (0.8)	0.9 (0.9)	<0.0001
Mood disorder	0.7 (0.9)	1.1 (0.9)	<0.0001
Sexual dysfunction	0.4 (0.7)	0.5 (0.8)	0.0114
Miscellaneous	2.2 (1.4)	2.8 (1.3)	<0.0001
Total score	12.8 (5.6)	16.2 (5.6)	<0.0001

APD: advanced Parkinson’s disease; NMSQ: Nonmotor Symptoms Questionnaire; SD: standard deviation.