Parkinson’s Disease / 2021 / Article / Tab 5 / Research Article
Off Time Independently Affects Quality of Life in Advanced Parkinson’s Disease (APD) Patients but Not in Non-APD Patients: Results from the Self-Reported Japanese Quality-of-Life Survey of Parkinson’s Disease (JAQPAD) Study Table 5 Multiple regression analysis for PDQ-8 SI in patients with APD.
Univariate model Multivariate initial model Multivariate final model backward elimination CE 95% CI valueCE 95% CI valueCE Standardized CE 95% CI valueDuration of off time 1.136 0.680, 1.593 <0.0001 1.015 0.579, 1.452 <0.0001 1.106 0.13 0.678, 1.533 <0.0001 Age 0.233 0.091, 0.374 0.0013 0.114 −0.028, 0.256 0.1141 0.154 0.06 0.023, 0.286 0.0212 Sex (ref: female) 3.399 1.137, 5.661 0.0033 1.059 −1.092, 3.210 0.3342 Duration of PD 0.615 0.454, 0.777 <0.0001 0.389 0.219, 0.558 <0.0001 0.369 0.119 0.211, 0.527 <0.0001 Work status (ref: unemployed) −4.746 −8.936, −0.556 0.0264 −1.481 −5.404, 2.442 0.4588 Number of PD medication types 1.183 0.750, 1.615 <0.0001 0.071 −0.374, 0.517 0.7531 NMSQ-TS 2.155 1.972, 2.339 <0.0001 2.028 1.834, 2.222 <0.0001 2.047 0.557 1.860, 2.235 <0.0001 WOQ-9 (ref: absence) −2.095 −4.893, 0.703 0.1422 −1.718 −4.422, 0.985 0.2126
APD: advanced Parkinson’s disease; CE: coefficient estimate; CI: confidence interval; NMSQ-TS: Nonmotor Symptoms Questionnaire Total Score; PD: Parkinson’s disease; PDQ-8 SI: 8-item Parkinson’s Disease Questionnaire Summary Index; ref: reference; WOQ-9: 9-item Wearing-Off Questionnaire.