Evaluation of Brain SPECT with ^99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism

Table 1

Clinical and epidemiological data of the groups with Parkinsonism.

Variables	Synucleinopathies (SNP)			^(SNP)	Tauopathies (TP)		^(TP)	^(TP × SNP)	DIP (19)	^(DIP × SNP)	^(DIP × PD)	VP (13)	p^(VP × SNP)	p^(VP × PD)
	PD (93)	MSA (7)	LBD (16)		PSP (2)	CBD (3)
Gender—female (%)	55 (59.1%)	5 (71.4)	8 (50%)	0.614	1 (50%)	0 (0%)	0.40	0.592	13 (68.4%)	0.650	0.607	9 (69.2%)	0.675	0.558
Average age (years)	65.09 ± 12.5	65.1 ± 10.4	72.8 ± 7.6	0.051	73.0 ± 5.7	63.3 ± 13.1	0.206	0.093	72.11 ± 10.74	0.017	0.012	75.62 ± 8.36	0.004	0.002
Duration of illness (years)	3.58 ± 4.86	1.38 ± 0.99	1.7 ± 1.26	0.159	1.5 ± 0.71	2.6 ± 2.15	0.273	0.141	1.34 ± 1.29	0.002	0.024	4.30 ± 4.42	0.060	0.307
Education (years)	9.39 ± 4.98	7.57 ± 5.26	6.81 ± 4.40	0.154	9.0 ± 7.07	7.0 ± 3.61	0.346	0.317	5.89 ± 4.07	0.032	0.002	6.08 ± 3.88	0.073	0.011
UPDRS	29.1 ± 11.9	32.7 ± 16.0	37.5 ± 16.4	0.097	48.0 ± 17.0	63.7 ± 8.4	0.123	0.00004	28.8 ± 11.7	0.183	0.470	31.8 ± 16.9	0.219	0.228
H&Y stage
1	4 (4.3%)	0 (0%)	2 (12.5%)	0.001	0 (0.0%)	0 (0.0%)	0.528	0.001	0 (0.0%)	0.040	0.998	1 (7.7%)	0.002	0.044
2	51 (54.8%)	2 (28.6%)	2 (12.5%)		0 (0.0%)	0 (0.0%)			13 (68.4%)			1 (7.7%)
3	34 (36.6%)	3 (42.9%)	10 (62.5%)		2 (100.0%)	1 (33.3%)			6 (31.6%)			6 (46.2%)
4	4 (4.3%)	2 (28.6%)	2 (12.5%)		0 (0.0%)	(2) 66.7%			0 (0.0%)			5 (38.5%)
Clinical presentation
Mixed/classic	62 (66.7%)	2 (28.6%)	1 (6.25%)	0.0002	0 (0%)	0 (0%)	1	<0.00001	17 (89.45%)	0.002	0.055	0 (0%)	0.0002	0.0001
Akinetic-rigid form	31 (33.3)	5 (71.4%)	15 (93.8%)		2 (100%)	3 (100%)			2 (10.55%)			13 (100%)
Nonmotor signs
Depression	52 (55.9%)	3 (42.9%)	11 (68.8%)	0.736	0 (0%)	0 (0%)	0.876	0.076	12 (63.2%)	1	0.619	5 (38.5%)	0.999	0.254
Constipation	58 (62.37%)	5 (71.4%)	8 (50%)	0.546	1 (50%)	3 (100%)	0.40	0.550	9 (47.37%)	0.478	0.304	7 (53.85%)	0.690	0.763
RLS	32 (34.4%)	0 (0%)	2 (12.5%)	0.135	1 (50%)	2 (66.7%)	1	0.143	4 (21.05%)	0.141	0.295	1 (7.7%)	0.020	0.059
RSBD	68 (73.1%)	5 (71.4%)	12 (75.0%)	0.313	2 (100%)	2 (66.7%)	1	0.640	10 (52.6%)	0.362	0.298	6 (46.2%)	0.262	0.217
DRSBD	18.9 ± 34.39	4.29 ± 8.98	23.63 ± 41.36	0.768	24.0 ± 33.94	0	0.136	0.664	6.0 ± 16.85	0.738	0.054	16.62 ± 36.18	0.839	0.411

PD: Parkinson’s disease, MSA: multiple system atrophy, LBD: Lewy body dementia, SNP: synucleinopathies, TP: tauopathies, PSP: progressive supranuclear palsy, CBD: cortico-basal degeneration, DIP: drug-induced Parkinsonism, VP: vascular Parkinsonism, RLS: restless legs syndrome, RSBD: REM sleep behavioral disorder, DRSBD: duration of REM sleep disorder. ^∗p<0.05 indicated statistical significance.