Evaluation of Brain SPECT with ^99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism

Table 2

Correlations of the brain SPECT with ^99mTc-TRODAT-1 of the groups with Parkinsonism.

Variables	Synucleinopathies (SNP)			(SNP)	(PD × MSA)	(PD × LBD)	Tauopathies (TP)		(TP)	(TP × SNP)	(TP × PD)	DIP (19)	(DIP × SNP)	(DOP × PD)	VP (13)	(VP × SNP)	(VP × PD)
	PD (93)	MSA (7)	LBD (16)				PSP (2)	CBD (3)
Regarding normality (%)	93 (100%)	7 (100%)	16 (100%)	1			2 (100%)	3 (100%)	1	1	1	11 (57.9%)	<0.0001	<0.0001	10 (77.0%)	<0.0001	0.0001
Abnormal exam
Severity of the alterations
Normal or zero	0 (0%)	0 (0%)	0 (0%)	0.199	0.209	0.814	0 (0%)	0 (0%)	0.764	0.685	0.863	8 (42.1%)	<0.0001	<0.0001	3 (23.1%)	<0.0001	<0.0001
Mild reduction or 1	1 (1.1%)	1 (14.3%)	0 (0%)				0 (0%)	0 (0%)				4 (21.1%)			2 (15.4%)
Moderate reduction or 2	19 (20.4%)	1 (14.3%)	3 (18.7%)				1 (50%)	1 (33.3%)				7 (36.8%)			3 (23.1%)
Accentuate reduction or 3	56 (60.2%)	4 (57.1%)	8 (50%)				0 (0%)	2 (66.7%)				0 (0%)			5 (38.5%)
Severe reduction or 4	17 (18.3%)	1 (14.3%)	5 (31.3%)				1 (50%)	0 (0%)				0 (0%)			0 (0%)
Symmetry of the abnormal (%)
Asymmetric	77 (82.6%)	6 (85.7%)	13 (81.3%)	0.999	1	0.999	1 (50%)	3 (100%)	0.400	0.974	0.713	8 (42.1%)	<0.0001	<0.0001	6 (46.2%)	<0.0001	<0.0001
Symmetric	16 (17.2%)	1 (14.3%)	3 (18.7%)				1 (50%)	0 (0%)				3 (15.8%)			4 (30.8%)
Normal	0 (0%)	0 (0%)	0 (0%)				0 (0%)	0 (0%)				8 (42.1%)			3 (23.1%)
Laterality symptoms
Unilateral	89 (95.7%)	6 (85.71%)	13 (81.25%)	0.051	0.309	0.063	1 (50%)	3 (100%)	0.400	0.036	0.105	14 (73.78%)	0.028	0.006	8 (61.53%)	0.002	0.001
Left	35 (37.6%)	1 (14.3%)	8 (50%)				0 (0%)	2 (66.7%)				5 (26.3%)			2 (15.4%)
Right	54 (58.1%)	5 (71.4%)	5 (31.3%)				1 (50%)	1 (33.3%)				9 (47.4%)			6 (46.2%)
Undefined—bilateral	4 (4.3%)	1 (14.3%)	3 (18.8%)				1 (50%)	0 (0%)				5 (26.3%)			5 (38.5%)
Laterality-SPECT-TRODAT
Unilateral	76 (81.72%)	6 (87.71%)	13 (81.25%)	0.999	1	1	1 (50%)	3 (100%)	0.400	0.394	0.717	11 (57.9%)	0.227	0.033	6 (46.2%)	0.065	0.009
Left	43 (46.2%)	3 (42.9%)	7 (43.8%)				1 (50%)	0 (0%)				8 (42.1%)			5 (38.5%)
Right	33 (35.5%)	3 (42.9%)	6 (37.5%)				0 (0%)	3 (100%)				3 (15.8%)			1 (7.7%)
Undefined—bilateral	17 (18.3%)	1 (14.3%)	3 (18.8%)				1 (50%)	0 (0%)				8 (42.1%)			7 (53.8%)
Laterality corresponding to the most affected side (%)
Yes	68 (73.18)	5 (71.42)	11 (68.75)	0.689 (sim × não) 0.041 (bilat × contra)	1 (sim × não) 0.306 (bilat × contra)	0.508 (sim × não) 0.052 (bilat × contra)	2 (100%)	2 (66.6%)	1 (sim × não) 1 (bilat × contra)	0.807 (sim × não) 0.059 (bilat × contra)	0.938 (sim × não) 0.254 (bilat × contra)	17 (89.5%) (89.47%)	0.566 (sim × não) <0.0001 (bilat × contra)	1 (sim × não) <0.0001 (bilat × contra)	11 (84.6%) (84.61%)	0.824 (sim × não) <0.0001 (bilat × contra)	0.508 (sim × não) <0.0001 (bilat × contra)
Contralateral	64 (69%)	4 (57.1%)	8 (50%)				1 (50%)	2 (66.66%)				6 (31.6%)			4 (30.86%)
Bilateral	4 (4.3%)	1 (14.3%)	3 (18.75%)				1 (50%)	0 0%)				11 (58%)			7 (53.8%)
No	25 (26.9%)	2 (28.6%)	2 (12.5%)				0 (0%)	1 (33%)				2 (10.5%)			2
Ipsilateral	9 (9.7%)	1 (14.3%)	2 (12.5%)				0 (0%)	1 (33.33%)				1 (5.26%)			0 (0%)
Undefined	16 (17.2%)	1 (14.3%)	0				0 (0%)	0 (0%)				1 (5.26%)			2 (15.4%)

PD: Parkinson’s disease, MSA: multiple system atrophy, LBD: Lewy body dementia, SNP: synucleinopathies, TP: tauopathies, PSP: progressive supranuclear palsy, CBD: cortico-basal degeneration, DIP: drug-induced Parkinsonism, VP: vascular Parkinsonism, RLS: restless legs syndrome, RSBD: REM sleep behavioral disorder, DRSBD: duration of REM sleep disorder. ^∗p<0.05 indicated statistical significance.