Review Article

Posterior Tibial Nerve Stimulation for Overactive Bladder: Mechanism, Classification, and Management Outlines

Table 1

Summary of some trials compared with different kinds of PTNS and other treatments for OAB.

First author (year)RegionStudy typeStudy periodAgeTotal numberInterventionComparisonTreatment cycleFollow-upConclusion

Govier FE (2001)USAClinical trial; prospective2000-200157.453Percutaneous PTNSBaselineWeekly12 weeksReduction in mean daytime, nighttime voiding frequencies, and urge incontinence. Improvements in quality of life (QoL) indexes
Rostaminia G (2019)USARetrospectiveJanuary 2011-December 201772.7162Percutaneous PTNSBaselineOnce a week12 weeksImprovement in all three OAB symptoms and QoL
Jacomo RH (2020)BrazilClinical trialAugust 2017 to October 201868.6250Transcutaneous PTNSTranscutaneous para sacral nerve stimulation (TPSNS)Twice a week4 weeksBoth groups’ symptoms improved as measured by the ICIQ-OAB and ICIQSF, but TPTNS is more effective than TPSNS
Ramírez‐García I (2019)BarcelonaCase control; retrospective2015 and 201659.668Transcutaneous PTNSPercutaneous PTNSWeekly12 weeksBoth techniques lessened urgency incontinence, daytime frequency, and greatly improved the QoL
Padilha JF (2020)Brazil.Randomized controlled trial2019-2020>18 years99Transcutaneous PTNSTPSNS and placeboWeekly12 weeksNA
Martin-Garcia M (2019)EnglandRandomized controlled trialMarch 2015 and April 2016Over 18 years66Transcutaneous PTNSPercutaneous PTNSFlexible home-based sessions6 weeks, and 3 and 6 monthsSimilar positive result in both groups with less frequency, urgency, and improvement in QoL
Seth JH (2018)EnglandCase control; retrospectiveN\A46.448Transcutaneous PTNSBaselineOnce daily or weekly3, 8, 12, and 16 weeksSignificantly effective in the decrease of all OAB symptoms for treated patients
Ghijselings, L (2021)BelgiumRandomized controlled trial20215-12N\ATranscutaneous PTNSPercutaneous PTNS and sham controlNA12 weeksTPTNS is significantly effective like PPTNS in the management of OAB symptoms
H.M.K (2017)USACase control; retrospectiveN\A5415BlueWind Medical, Herzliya, IsraelBaseline6 times per week1 and 3 monthsSafe, effective, and well-tolerated the modality in OAB patient treatment
DorsthorstProspective56.134BlueWind RENOVA iStim systemBaselineAutomatic36 monthsThe OAB symptoms significantly improved in treatment group.
MacDiarmid (2019)USA and New ZealandProspective63.446eCoinBaselineAutomated stimulation sessions3 and 6 monthseCoin showed safe and effective method in the treatment of OAB
Alexandra Rogers (2021)USACohort study; prospectiveAugust 14, 2018, to April 2, 201963.9137eCoinBaselineAutomated stimulation sessions48 weekseCoin demonstrated clinical benefits for treating overactive bladder