Identification of Potential miRNA-mRNA Regulatory Network Contributing to Parkinson’s Disease

Figure 2

miRNA target prediction and selection. The target prediction of each miRNA was conducted using miRDB, TargetScan, miRWalk, and miRTarBase databases. (a) The target genes of upregulated DEmis commonly predicted by 3 and 4 databases and simultaneously overlapped with the downregulated DEGs from the GSE100054 dataset were selected to construct the regulatory network. (b) The regulatory network of downregulated DEmis and their target genes selected from overlaps between upregulated DEGs from GSE100054 dataset and predicted targets by 3 and 4 databases.

(a)

(b)