Research Article
MAO-B Polymorphism Associated with Progression in a Chinese Parkinson’s Disease Cohort but Not in the PPMI Cohort
Table 4
Association between haplotypes and progression in the TW and PPMI cohorts.
| Cohort | HaploBlock | Haplotype | Prog | Estimate (95% CI) | value |
| PPMI | PARK16 haplotype | ACAG | GDS | 6375 (3028–9721) | 0.0002068 | ACCA | GDS | 6375 (3028–9721) | 0.0002068 | ATCA | GDS | 6375 (3028–9721) | 0.0002068 | GCCA | GDS | 6375 (3028–9721) | 0.0002068 | GCAG | GDS | 6375 (3028–9721) | 0.0002069 | GTCA | GDS | 6719 (3192–10247) | 0.0002070 | ATCG | GDS | 6375 (3028–9721) | 0.0002068 | ACCG | GDS | 430472 (204429–656514) | 0.0002077 | ACAG | STAI | 42709 (17981–67436) | 0.0007535 | ACCA | STAI | 42709 (17982–67437) | 0.0007534 | ATCA | STAI | 42709 (17982–67436) | 0.0007534 | GCCA | STAI | 42708 (17981–67435) | 0.0007534 | GCAG | STAI | 42711 (17983–67438) | 0.0007531 | GTCA | STAI | 45020 (18954–71085) | 0.0007534 | ATCG | STAI | 42709 (17982–67436) | 0.0007534 | ACCG | STAI | 2884040 (1213734–4554345) | 0.0007563 | SNCA haplotype | AGTGCA | Hoehn-Yahr staging | 255 (161–348) | <0.000001 | PPMI | SNCA haplotype | AGTGCA | Motor PC1 | −3090 (-4978–1201) | 0.0014101 |
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GDS, geriatric depression scale; PC, principal component; STAI, state-trait anxiety inventory for adults.
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