Short-Term Motor Outcomes in Parkinson’s Disease after Subthalamic Nucleus Deep Brain Stimulation Combined with Post-Operative Rehabilitation: A Pre-Post Comparison Study
Table 2
Results of post-operative rehabilitation with STN-DBS.
PRE
POST
DISC
value ANOVA
Fvalue
value (PRE-POST)
value (PRE-DISC)
value (POST-DISC)
Mini-BESTest
19.8 (5.1)
20.3 (4.8)
23.1 (4.3)
<0.0001
32.2
N.S
TUG seconds
10.4 (4.0)
11.3 (6.0)
9.7 (3.3)
0.053
3.0
N.S
N.S
N.S
TUG steps
17.1 (7.2)
17.1 (6.5)
14.7 (3.7)
0.003
6.1
N.S
TUG-cog seconds
14.4 (7.3)
15.9 (14.1)
12.2 (4.7)
0.046
3.2
N.S
N.S
TUG-cog steps
23.2 (15.8)
22.1 (10.9)
17.5 (5.3)
0.005
5.6
N.S
TIS
17.3 (3.8)
17.5 (3.1)
18.8 (2.5)
<0.0001
11.8
N.S
10 times toe-tapping time (seconds)
4.4 (1.4)
4.0 (0.8)
3.8 (0.8)
0.0008
7.7
N.S
StrengthErgo240 (Newton-meter)
143.1 (71.6)
142.9 (73.5)
157.9 (74.8)
<0.0001
15.0
N.S
Eyes opened standing
COP 95% range circle (mm2)
1175.5 (2206.3)
1077.9 (1274.7)
1293.3 (1906.7)
0.80
0.2
N.S
N.S
N.S
COP path length (mm)
632 (587.9)
705.5 (654.7)
794.6 (687.0)
0.41
0.9
N.S
N.S
N.S
COP average speed (mm/sec)
21.7 (18.6)
22.8 (21.0)
24.0 (21.0)
0.89
0.1
N.S
N.S
N.S
Eyes closed standing
COP 95% range circle (mm2)
1029.2 (1162.9)
1150.1 (1588.5)
2027.4 (2835.6)
0.011
4.7
N.S
COP path length (mm)
880.9 (726.7)
926.0 (811.8)
1200.4 (1174.8)
0.04
3.4
N.S
COP average speed (mm/sec)
22.8 (20.3)
28.2 (25.6)
36.7 (35.8)
0.007
5.2
N.S
LDD
740 (272)
767 (240)
332 (218)
<0.0001
109.2
N.S
LEDD
1464 (490)
1462 (516)
847 (456)
<0.0001
208.8
N.S
Data are mean (SD), ,. abbreviations: PRE, preoperation; POST, postoperation; DISC, discharge; TUG, timed up and go test; TUG-cog, timed up and go test cognitive tasking; TIS, trunk impairment scale; mini-BESTest, mini-balance evaluation systems test; LDD, levodopa daily dose; LEDD, levodopa equivalent daily dose; COP, center of pressure.
