Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features

Table 1

DaTscan EWAS summary statistics.

Chr	SNP	Effect allele	Effect allele frequency	Effect size	SE	Mapped gene	DaTscan anatomical feature	value
1	rs10864219	A	0.49	0.19	0.04	USH2A	Right caudate	2.18 × 10^−5
1	rs78555129	G	0.10	0.29	0.07	C1QTNF12	Right caudate	0.00010
1	rs199737720	G	0.06	0.46	0.10	IGFN1	Left caudate	8.63 × 10^−6
				0.42	0.10		Left anterior putamen	8.89 × 10^−5
1	rs201465075	G	0.08	0.46	0.09	IGFN1	Left caudate	4.03 × 10^−7
				0.35	0.09		Right putamen	8.54 × 10^−5
				0.41	0.09		Left putamen	8.83 × 10^−6
				0.37	0.09		Right anterior putamen	6.48 × 10^−5
				0.43	0.09		Left anterior putamen	5.12 × 10^−6
2	rs112724571	A	0.05	−0.44	0.11	TMEM169	Left caudate	9.57 × 10^−5
3	rs41271391	T	0.12	−0.29	0.07	CD80	Left caudate	5.60 × 10^−5
3	rs16829980	G	0.12	−0.29	0.07	CD80	Left caudate	5.60 × 10^−5
3	rs2305035	A	0.22	0.22	0.05	CBLB	Left putamen	0.000112
4	rs17612630	A	0.20	0.25	0.06	DDX60L	Right putamen	2.93 × 10^−5
				0.24	0.06		Right anterior putamen	0.00010
4	rs6964	A	0.31	−0.21	0.05	GAK	Left anterior putamen	4.71 × 10^−5
5	rs6873053	A	0.08	0.35	0.09	TIMD4	Right putamen	9.33 × 10^−5
				0.36	0.09		Left putamen	0.00010
6	rs41266301	C	0.10	−0.30	0.07	KIF25	Left putamen	8.81 × 10^−5
6	rs3024466	A	0.16	0.27	0.06	F13A1	Right anterior putamen	3.85 × 10^−5
				0.27	0.06		Left anterior putamen	3.85 × 10^−5
6	rs1050783	T	0.16	0.27	0.06	F13A1	Right anterior putamen	3.15 × 10^−5
				0.27	0.06		Left anterior putamen	3.00 × 10^−5
7	rs41280648	A	0.05	−0.44	0.10	OGDH	Right caudate	4.40 × 10^−5
7	rs2906997	G	0.06	0.38	0.09	ZP3	Left caudate	0.000117
7	rs3800769	C	0.42	−0.18	0.04	SLC13A4	Left putamen	0.00010
				−0.21	0.04		Left anterior putamen	1.98 × 10^−5
8	rs2451153	A	0.34	−0.20	0.05	SAMD12	Right caudate	8.29 × 10^−5
8	rs2514743	C	0.35	−0.19	0.05	SAMD12	Right caudate	0.00010
8	rs2280838	C	0.44	−0.17	0.04	SLC39A4	Right putamen	0.00010
9	rs15394	C	0.15	−0.26	0.06	CTSV	Right caudate	8.07 × 10^−5
9	rs62560873	A	0.14	−0.26	0.06	GAS2L1P2	Right caudate	9.54 × 10^−5
				−0.28	0.06		Right putamen	2.69 × 10^−5
				−0.27	0.07		Left putamen	7.70 × 10^−5
				−0.28	0.07		Right anterior putamen	5.84 × 10^−5
				−0.29	0.07		Left anterior putamen	4.30 × 10^−5
9	rs16924211	G	0.14	−0.29	0.06	GAS2L1P2	Right caudate	9.81 × 10^−6
				−0.29	0.06		Left caudate	1.59 × 10^−5
				−0.29	0.06		Right putamen	8.81 × 10^−6
				−0.28	0.06		Left putamen	3.38 × 10^−5
				−0.30	0.06		Right anterior putamen	1.10 × 10^−5
				−0.30	0.07		Left anterior putamen	1.40 × 10^−5
12	rs12320366	T	0.13	0.28	0.06	KERA	Right caudate	3.61 × 10^−5
12	rs11615432	G	0.08	0.34	0.08	GALNT8/KCNA6	Right putamen	6.80 × 10^−5
12	rs7955650	C	0.05	0.44	0.10	TBC1D15	Left putamen	2.65 × 10^−5
				0.42	0.10		Left anterior putamen	7.46 × 10^−5
13	rs41288262	C	0.09	−0.32	0.08	POU4F1	Left caudate	6.73 × 10^−5
				−0.31	0.09		Left putamen	0.00010
13	rs61947037	C	0.43	−0.20	0.05	PARP4	Right anterior putamen	6.27 × 10^−5
18	rs13732	T	0.46	−0.18	0.04	FECH	Right caudate	0.000117
19	rs10401255	C	0.05	0.47	0.10	ZNF586	Left caudate	1.18 × 10^−5
				0.51	0.10		Right putamen	1.01 × 10^−6
				0.53	0.11		Left putamen	1.59 × 10^−6
				0.51	0.10		Right anterior putamen	1.94 × 10^−6
				0.50	0.11		Left anterior putamen	4.99 × 10^−6
19	rs16027	T	0.09	0.33	0.08	CACNA1A	Right putamen	6.10 × 10^−5
19	rs56283800	T	0.07	0.34	0.08	CYP2A6	Right putamen	7.64 × 10^−5
19	rs2270683	A	0.11	0.31	0.07	DACT3	Right putamen	3.13 × 10^−5
				0.32	0.07		Right anterior putamen	2.53 × 10^−5
21	rs2839531	T	0.07	0.37	0.09	RSPH1	Left anterior putamen	8.11 × 10^−5