Parkinson’s Disease

Mitochondria: Key Organelle in Parkinson’s Disease


Publishing date
17 Jun 2016
Status
Published
Submission deadline
29 Jan 2016

1University Medical Center Groningen, Groningen, Netherlands

2Gustave Roussy Cancer Campus, Villejuif, France

3Universidad de Extremadura, Cáceres, Spain

4University College London, London, UK


Mitochondria: Key Organelle in Parkinson’s Disease

Description

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized pathologically by loss of dopaminergic neurons in the substantia nigra pars compacta. As a consequence, PD patients show symptoms such as tremor, rigidity, or bradykinesia, but also nonmotor features (depression, sleep disorders, etc.). The etiology of PD is still unknown, involving genetic and environmental factors; however, mitochondrial dysfunction plays a central role in PD pathogenesis. In this regard, several PD-related proteins (PINK1, Parkin, DJ-1, LRRK2, and α-synuclein) are linked to mitochondria.

Mitochondria are highly dynamic organelles involved in essential cellular functions, including energy production, calcium homeostasis, metabolism of amino acids and lipids, mtDNA replication, programmed cell death, etc. Moreover, mitochondrial homeostasis is tightly regulated by several pathways, including mitochondrial biogenesis, remodeling (fusion/fission), and clearance of damaged mitochondria by autophagy (mitophagy), among others. Importantly, mitochondria and endoplasmic reticulum (ER) establish contact sites to maintain several of these pathways. Dopaminergic neurons are particularly sensitive to mitochondrial dysfunction, so alterations of these processes lead to a compromised cellular status.

Better understanding of mitochondrial quality control is essential in nondivisible cells, such as neurons, to prevent cell death and development of age-related neurodegenerative disorders (e.g., PD). Current therapeutic strategies in PD are based on slowing down the disease progression. However, they are not successful and potential clinical agents should be based on early biomarkers for PD and mitochondrial dysfunction is one of the most promising targets to be studied. The aim of this special issue is to provide new insights into molecular and cellular pathways related to mitochondria that influence the pathogenesis of PD to further develop new therapeutic approaches.

We invite investigators to contribute original research articles, review articles, and clinical studies that will help in the elucidation of the role of mitochondria in PD, to delay the onset and/or reduce the progression of this disease.

Potential topics include, but are not limited to:

  • Mitochondrial dysfunction in the pathogenesis of PD
  • Mitochondrial oxidative stress and antioxidant therapy in PD
  • Mitochondrial biogenesis, dynamics (fission/fusion), and motility in PD
  • Mitophagy
  • Relationship between mitochondria and ER in PD
  • Preclinical studies in animal models of PD
  • Mitochondrial therapies for PD

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 6230370
  • - Editorial

Mitochondria: Key Organelle in Parkinson’s Disease

Rubén Gómez-Sánchez | José M. Bravo-San Pedro | ... | José M. Fuentes
  • Special Issue
  • - Volume 2016
  • - Article ID 2613401
  • - Review Article

Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson’s Disease

Ruixin Yang | Guodong Gao | ... | Qian Yang
  • Special Issue
  • - Volume 2016
  • - Article ID 7049108
  • - Review Article

Parkinson’s Disease: The Mitochondria-Iron Link

Yorka Muñoz | Carlos M. Carrasco | ... | Marco T. Núñez
  • Special Issue
  • - Volume 2016
  • - Article ID 7351985
  • - Review Article

Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

Katharina E. Rosenbusch | Arjan Kortholt
  • Special Issue
  • - Volume 2016
  • - Article ID 9531917
  • - Research Article

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2

Shaun Martin | Sarah van Veen | ... | Peter Vangheluwe
  • Special Issue
  • - Volume 2016
  • - Article ID 1819209
  • - Research Article

Altered Mitochondrial Respiration and Other Features of Mitochondrial Function in Parkin-Mutant Fibroblasts from Parkinson’s Disease Patients

William Haylett | Chrisna Swart | ... | Soraya Bardien
  • Special Issue
  • - Volume 2016
  • - Article ID 2405176
  • - Research Article

A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain

Rachit Bakshi | Shuchi Mittal | ... | Clemens R. Scherzer
  • Special Issue
  • - Volume 2016
  • - Article ID 4686185
  • - Research Article

Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis

Georg Auburger | Suzana Gispert | Nadine Brehm
Parkinson’s Disease
 Journal metrics
Acceptance rate39%
Submission to final decision99 days
Acceptance to publication31 days
CiteScore2.270
Impact Factor2.051
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