Parkinson’s Disease

Inflammation and Parkinson's Disease


Publishing date
15 Apr 2011
Status
Published
Submission deadline
15 Oct 2010

Lead Editor

1Clinical and Experimental Neuroscience, CIBERNED, Department of Anatomy, School of Medicine, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain

2CRICM, INSERM/UPMC UMR_S975 (ex U679), CNRS UMR 7225, Experimental Therapeutics on Neurodegeneration, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France

3Department of Pharmacology, University of New South Wales, Wallace Wurth Building, Sydney, NSW 2052, Australia

4Instituto Leloir, IIBBA-CONICET, Avenue Patricias Argentinas 435 (1405), Buenos Aires, Argentina


Inflammation and Parkinson's Disease

Description

In the field of neurodegenerative diseases, the concept of noncell autonomous disease mechanisms suggests that neurodegeneration is not just mediated by damages within the affected neurons but is also influenced by interactions with neighboring glial and peripheral immune cells invading the injured brain. The neuroinflammatory response, a major component of these noncell autonomous mechanisms, produces culprits that could represent the core of the progressive nature of neurodegenerative diseases including Parkinson's disease (PD). Indeed, growing evidence from epidemiological, post mortem, and animal studies suggest that both the innate and adaptive arms of the immune system could participate in the progression of dopaminergic cell death in PD. Yet, in spite of unquestionable major advances made in the field of neuroimmune interactions in PD, the precise identity, origin, and function of the various innate and adaptive immune cells involved in response to dopaminergic degeneration have not been completely identified. Settling these questions is crucial to accurately depict the mechanism of cell death in PD and also to develop therapeutic strategies that selectively target the cytotoxic arm without altering the beneficial function of immune cells.

The main focus of this special issue will be on clinical and basic studies investigating all aspects of the inflammatory response and neuron-immune interactions in PD. We particularly take interest in manuscripts reporting new clinical evidences showing inflammatory alterations in patients with PD, new antiinflammatory treatments that may improve their prognosis, as well as studies of basic science in disease models depicting the mechanisms of neuroinflammation and/or demonstrating the beneficial effects of antiinflammatory drugs. Main topics include, but are not limited to:

  • Systemic immune alterations/deviations in PD patients: cellular and molecular characteristics of peripheral innate and adaptive immune responses
  • Central immune responses in PD: glial cell response to dopaminergic degeneration, involvement of peripheral immune cells in the central inflammatory response
  • Immunity and PD etiopathogenesis: impact of systemic inflammation, viral infection, and environmental factors on risk or disease progression
  • Preclinical studies of immune-based therapeutics: antiinflammatory drugs and immunization
  • Clinical studies: case reports and clinical trials
  • Epidemiological studies: large population studies correlating the influence of antiinflammatory treatments, genetic polymorphisms on inflammatory genes or infections, and risk or PD progression

Both original scientific papers and review articles on the above topics will be considered for publication.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/pd/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 729054
  • - Editorial

Inflammation and Parkinson's Disease

Carlos Barcia | Stéphane Hunot | ... | Fernando Pitossi
  • Special Issue
  • - Volume 2011
  • - Article ID 716859
  • - Review Article

The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease

Anna Zinger | Carlos Barcia | ... | Gilles J. Guillemin
  • Special Issue
  • - Volume 2011
  • - Article ID 931572
  • - Review Article

The Degenerating Substantia Nigra as a Susceptible Region for Gene Transfer-Mediated Inflammation

Valeria Roca | Juan Cruz Casabona | ... | Fernando Juan Pitossi
  • Special Issue
  • - Volume 2011
  • - Article ID 327089
  • - Review Article

Lipopolysaccharide Animal Models for Parkinson's Disease

Mei Liu | Guoying Bing
  • Special Issue
  • - Volume 2011
  • - Article ID 393769
  • - Review Article

Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence

A. Machado | A. J. Herrera | ... | J. Cano
  • Special Issue
  • - Volume 2011
  • - Article ID 216298
  • - Review Article

Transcriptional Factor NF- B as a Target for Therapy in Parkinson's Disease

Patrick M. Flood | Li Qian | ... | Jau-Shyong Hong
  • Special Issue
  • - Volume 2011
  • - Article ID 689181
  • - Review Article

Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?

Anna R. Carta | Augusta Pisanu | Ezio Carboni
  • Special Issue
  • - Volume 2011
  • - Article ID 436813
  • - Review Article

Parkinson's Disease and Systemic Inflammation

Carina C. Ferrari | Rodolfo Tarelli
  • Special Issue
  • - Volume 2011
  • - Article ID 247467
  • - Review Article

Lipid-Mediated Oxidative Stress and Inflammation in the Pathogenesis of Parkinson's Disease

Tahira Farooqui | Akhlaq A. Farooqui
  • Special Issue
  • - Volume 2011
  • - Article ID 713517
  • - Review Article

Inflammatory Mechanisms of Neurodegeneration in Toxin-Based Models of Parkinson's Disease

Darcy Litteljohn | Emily Mangano | ... | Shawn Hayley
Parkinson’s Disease
 Journal metrics
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Acceptance rate22%
Submission to final decision119 days
Acceptance to publication18 days
CiteScore5.200
Journal Citation Indicator0.730
Impact Factor3.2
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