The Potential Role of Hemopexin and Heme Oxygenase-1 Inducer in a Model of Sepsis

Figure 5

Histopathological changes of liver and lung sections of the four experimental groups. Liver and lung sections were stained with H&E and examined by light microscopy (magnification ×40 and ×100 for liver and lung, resp.). (a) Liver tissue—CG: normal liver section of the control group with no pathological changes. CLP group: dense (severe) portal lymphocytic infiltration (arrow) and diffuse macro- and microvesicular fatty changes in hepatocytes (arrow heads). CLP + Hm: focal microvesicular fatty changes in hepatocytes (arrow heads). CLP + HPx: moderate portal lymphocytic infiltration (arrow) and diffuse microvesicular fatty changes in hepatocytes (arrow heads). (b) Lung tissue—CG: lung, thin walled alveoli, no inflammation, and mild congestion. CLP group: thick walled alveoli with dense inflammation, congestion, and numerous thrombi (arrows). CLP + Hm: thin walled alveoli with mild thickness, moderate inflammation, mild congestion, and few thrombi (arrow). CLP + HPx: thin walled alveoli with mild thickness, inflammation, congestion, and few thrombi (arrow).

(a) Liver tissue

(b) Lung tissue