Research Article
Is PiSS Alpha-1 Antitrypsin Deficiency Associated with Disease?
Table 1
Published research on Alpha-1 antitrypsin population genetics when PiSS was reported.
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*Included in the MM genotype is the E polymorphism which is situated in the 3’ noncoding enhancer binding region. †NA: Not Available. This study did not indicate whether the individuals with the PiSS genotype were diagnosed with any lung/liver disease or had the presence of any symptoms. ‡Sixteen of 34 individuals tested were interviewed to obtain this frequency of any lung disease. §Registry participants identified the presence of lung disease at study entry. Three of these are included in the study cohort of this paper. Lung diseases reported in all 5 individuals with PiSS include COPD, = 2, Asthma, = 3, and Frequent pneumonia, = 2. |