Is PiSS Alpha-1 Antitrypsin Deficiency Associated with Disease?

Table 5

Case-control series of individuals with COPD and asthma in which at least one individual with the PiSS genotype has been identified.

	Case	Control
COPD
Kueppers et al. [15]	0/114 (0%)	1/114 (0.9%)
Lieberman et al. [16]	3/965 (0.31%)	1/1380 (0.07%)
Sandford et al. [17]	2/193 (1.04%)	0/73 (0%)
Mittman et al. [18]	1/240 (0.42%)	0.1/240 (0.04%)
Allergy and nonatopic infantile asthma
Ihrig et al. [19]	0/138 (0%)	5*/700 (0.71%)
Arnaud et al. [20]	2/298 (0.67%)	23/1653 (1.39%)

*Not indicated whether these five participants were PiSS or PiSZ genotypes.