Research Article
Is PiSS Alpha-1 Antitrypsin Deficiency Associated with Disease?
Table 5
Case-control series of individuals with COPD and asthma in which at least one individual with the PiSS genotype has been identified.
| | Case | Control |
| COPD |
| Kueppers et al. [15] | 0/114 (0%) | 1/114 (0.9%) | Lieberman et al. [16] | 3/965 (0.31%) | 1/1380 (0.07%) | Sandford et al. [17] | 2/193 (1.04%) | 0/73 (0%) | Mittman et al. [18] | 1/240 (0.42%) | 0.1/240 (0.04%) |
| Allergy and nonatopic infantile asthma |
| Ihrig et al. [19] | 0/138 (0%) | 5*/700 (0.71%) | Arnaud et al. [20] | 2/298 (0.67%) | 23/1653 (1.39%) |
|
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*Not indicated whether these five participants were PiSS or PiSZ genotypes.
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