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Pulmonary Medicine
Volume 2011 (2011), Article ID 240805, 5 pages
http://dx.doi.org/10.1155/2011/240805
Clinical Study

Ganciclovir Antiviral Therapy in Advanced Idiopathic Pulmonary Fibrosis: An Open Pilot Study

1Advanced Lung Disease and Lung Transplant Programme, Department of Respiratory Medicine, Mater Misericordiae University Hospital, University College Dublin, Eccles Street, Dublin 7, Ireland
2Respiratory Research Group, University of Manchester, Manchester Academic Health Sciences Centre, UK
3Division of Medical Microbiology and Genitourinary Medicine, University of Liverpool, UK
4NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester, UK

Received 27 October 2010; Accepted 7 February 2011

Academic Editor: Patrick Mallia

Copyright © 2011 J. J. Egan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. E. King, M. I. Schwarz, K. Brown et al., “Idiopathic Pulmonary Fibrosis: relationship between histopathologic features and mortality,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 6, pp. 1025–1032, 2001. View at Google Scholar · View at Scopus
  2. J. M. Vergnon, M. Vincent, G. De The et al., “Cryptogenic fibrosing alveolitis and Epstein-Barr virus: an association?” Lancet, vol. 2, no. 8406, pp. 768–770, 1984. View at Google Scholar · View at Scopus
  3. J. J. Egan, J. P. Stewart, P. S. Hasleton, J. R. Arrand, K. B. Carroll, and A. A. Woodcock, “Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis,” Thorax, vol. 50, no. 12, pp. 1234–1239, 1995. View at Google Scholar · View at Scopus
  4. J. P. Stewart, J. J. Egan, A. J. Ross et al., “The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis,” American Journal of Respiratory and Critical Care Medicine, vol. 159, no. 4 I, pp. 1336–1341, 1999. View at Google Scholar · View at Scopus
  5. K. M. Vannella, T. R. Luckhardt, C. A. Wilke, L. F. Van Dyk, G. B. Toews, and B. B. Moore, “Latent herpesvirus infection augments experimental pulmonary fibrosis,” American Journal of Respiratory and Critical Care Medicine, vol. 181, no. 5, pp. 465–477, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. A. L. Mora, E. Torres-González, M. Rojas et al., “Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-γ receptor-deficient mice,” American Journal of Respiratory and Critical Care Medicine, vol. 175, no. 11, pp. 1139–1150, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. “Idiopathic Pulmonary Fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society and the European Respiratory Society,” American Journal of Respiratory and Critical Care Medicine, vol. 161, pp. 646–664, 2000.
  8. E. Moloney, N. Clayton, D. K. Mukherjee, C. G. Gallagher, and J. J. Egan, “The shuttle walk exercise test in idiopathic pulmonary fibrosis,” Respiratory Medicine, vol. 97, no. 6, pp. 682–687, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. A. U. Wells, D. M. Hansell, N. K. Harrison, R. Lawrence, C. M. Black, and R. M. Du Bois, “Clearance of inhaled 99mTc-DTPA predicts the clinical course of fibrosing alveolitis,” European Respiratory Journal, vol. 6, no. 6, pp. 797–802, 1993. View at Google Scholar · View at Scopus
  10. E. Gabbay, R. Tarala, R. Will et al., “Interstitial lung disease in recent onset rheumatoid arthritis,” American Journal of Respiratory and Critical Care Medicine, vol. 156, no. 2 I, pp. 528–535, 1997. View at Google Scholar · View at Scopus
  11. N. Mogulkoc, M. H. Brutsche, P. W. Bishop et al., “Greater manchester pulmonary fibrosis consortium. Pulmonary (99m)Tc-DTPA aerosol clearance and survival in usual interstitial pneumonia (UIP),” Thorax, vol. 56, no. 12, pp. 916–923, 2001. View at Google Scholar
  12. K. Tsukamoto, H. Hayakawa, A. Sato, K. Chida, H. Nakamura, and K. Miura, “Involvement of Epstein-Barr virus latent membrane protein 1 in disease progression in patients with idiopathic pulmonary fibrosis,” Thorax, vol. 55, no. 11, pp. 958–961, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. I. W. Tang, J. E. Johnson, P. J. Browning et al., “Herpesvirus DNA is consistently detected in lungs of patients with idiopathic Pulmonary Fibrosis,” Journal of Clinical Microbiology, vol. 41, no. 6, pp. 2633–2640, 2003. View at Google Scholar · View at Scopus