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Pulmonary Medicine
Volume 2011 (2011), Article ID 293285, 4 pages
http://dx.doi.org/10.1155/2011/293285
Case Report

Congenital Cytomegalovirus Infection Manifesting as Neonatal Persistent Pulmonary Hypertension: Report of Two Cases

1Service de Néonatologie, Hôpital Armand Trousseau, AP-HP, Faculté de Médecine, Université Pierre et Marie Curie, 75012 Paris, France
2Service de Réanimation Néonatale, Hôpital Universitaire D'Angers, 49033 Angers, France
3Laboratoire de Virologie, Hôpital Necker-Enfants Malades, AP-HP, Faculté de Médecine, Université Paris-Descartes, 75015 Paris, France
4Service de Réanimation Polyvalente Pédiatrique et Néonatale, Hôpital Necker-Enfants Malades, AP-HP, Faculté de Médecine, Université Paris-Descartes, 75015 Paris, France

Received 13 January 2011; Accepted 18 April 2011

Academic Editor: Dimitris Georgopoulos

Copyright © 2011 Elizabeth Walter-Nicolet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Various neonatal symptoms can lead to a diagnosis of congenital CMV infection. We report two cases of persistent pulmonary hypertension in relation with congenital CMV infection following maternal primary infection and reinfection, respectively. Both infants had severe refractory hypoxemia, requiring high-frequency ventilation, inhaled nitric oxide and inotropic support. One of them required extracorporeal membrane oxygenation for five days. Ganciclovir therapy was attempted in the two cases on day 12 postnatal. One of the infant died on day 15 postnatal. The other survived and is developing uneventfully at 15 months of age. Conclusion: Neonatal persistent pulmonary hypertension can be the consequence of congenital CMV infection. Intensive respiratory support and IV ganciclovir are indicated in case of life-threatening condition.