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Pulmonary Medicine
Volume 2011, Article ID 381787, 11 pages
Research Article

Pulmonary Hypertension Related to Left-Sided Cardiac Pathology

Division of Cardiology, Duke University Medical Center, P.O. Box 3102, Durham, NC 27710, USA

Received 10 January 2011; Revised 2 April 2011; Accepted 2 April 2011

Academic Editor: Aldo T. Iacono

Copyright © 2011 Todd L. Kiefer and Thomas M. Bashore. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pulmonary hypertension (PH) is the end result of a variety of diverse pathologic processes. The chronic elevation in pulmonary artery pressure often leads to right ventricular pressure overload and subsequent right ventricular failure. In patients with left-sided cardiac disease, PH is quite common and associated with increased morbidity and mortality. This article will review the literature as it pertains to the epidemiology, pathogenesis, and diagnosis of PH related to aortic valve disease, mitral valve disease, left ventricular systolic and diastolic dysfunction, and pulmonary veno-occlusive disease. Moreover, therapeutic strategies, which focus on treating the underlying cardiac pathology will be discussed.