Factors Influencing Oxidative Imbalance in Pulmonary Fibrosis: An Immunohistochemical Study

Table 2

Profile and score of immunohistochemical expression in relevant lung cell types.

	Type I pn	Type II pn	Bronchiolar epithelial	UIP fibroblast foci			COP endoalveolar plugs		Macrophages
				Overlaying pneumocytes	Squamous metaplastic cells	Fibroblasts	Reactive pneumocytes	Fibroblasts
RAGE	+	+++	+	+++	+++	+++	+++	+++	+++
MnSOD	−	+++	++	+++	++	−	+++	+	+++
ECSOD	−	+++	+	++	+	−	++	++	+++
i-NOS	−	+	−	+	++	−	+	+	+++
Nitrotyrosine	−	++	−	++	++	−	++	++	+++
NF-kB	−	−	−	−	−	−	−	−	−
Ph-SMAD2	+	+	+	+	+	+	+	+	+
SMAD3	−	+*	−	+	−	−	++*	+*	+*

* Cytoplasmic expression.