Cell-Specific Dual Role of Caveolin-1 in Pulmonary Hypertension

Figure 3

This figure depicts the proposed model of PH (#2). Hypoxia causes perturbation of endothelial cell membrane, and caveolin-1 and eNOS form a tight complex rendering both molecules dysfunctional. eNOS dysfunction function leads to impaired NO availability and superoxide generation, and dysfunctional caveolin-1 loses its ability to inhibit proliferative pathways resulting in the activation of mitogenic pathways. The end results are pulmonary vascular remodeling and PH.