Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Review

Table 1

Prominent clinical studies evaluating gastroesophageal reflux in IPF.

Study	Methodology	Number of subjects	Prevalence of GERD	Other outcomes
Tobin et al. 1998 [35]	Prospective with non-IPF ILD control	17 IPF8 controls	94% IPF50% controls	25% of IPF patients had typical reflux symptoms
Raghu et al. 2006 [36]	Prospective, control group without ILD	65 IPF133 asthmatics	87% IPF68% Asthma	47% of IPF patients had heartburn and regurgitation. No significant difference in proximal reflux in IPF and asthma, 63% versus 61%, respectively
Raghu et al. 2006 [19]	Retrospective case review	4 IPF	100% as one of the inclusion criteria	2–6 year follow up with stable FVC and TLCO with proton pump inhibitors
Salvioli et al. 2006 [37]	Prospective	18 IPF10 secondarypulmonary fibrosis	67% of IPF patients had abnormal distal reflux	57% of total patients had heartburn and regurgitation
Bandiera et al. 2009 [38]	Prospective	28 IPF	35.7%	Participants divided into GRED^+ and GERD^− groups