Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice

Figure 3

Late rapamycin treatment does not reduce bleomycin-induced weight loss in 𝑆𝑓𝑡𝑝𝑐^−/− mice. (a) Diagram of experimental protocol for rescue studies to test affects of rapamycin on bleomycin induced lung fibrosis. 𝑆𝑓𝑡𝑝𝑐^−/− mice were treated with daily rapamycin or vehicle beginning 8 days following administration of intratracheal bleomycin or saline. (b) Body weights in mice receiving bleomycin decreased compared to saline-treated mice. (c) H&E images of mouse lungs 22 days after bleomycin administration. Images in panel (c) are 40x magnification.