Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice

Figure 4

Late rapamycin treatment does not reduce bleomycin-induced pulmonary fibrosis in 𝑆𝑓𝑡𝑝𝑐^−/− mice. 𝑆𝑓𝑡𝑝𝑐^−/− mice were treated with daily rapamycin or vehicle beginning 8 days following administration of intratracheal bleomycin or saline. (a)–(f) Mason’s trichrome staining demonstrates increased lung matrix deposition in bleomycin-administered mice (c)–(f) compared to saline-treated mice (a, b). (a, c, e) (10x magnification), (b, d, f) (40x magnification). (g) Total lung collagen was increased in mice receiving bleomycin compared to saline-treated mice. There were no differences in total lung collagen in bleomycin mice treated with rapamycin or vehicle.

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