Table of Contents Author Guidelines Submit a Manuscript
Pulmonary Medicine
Volume 2012, Article ID 351037, 8 pages
Research Article

Abdominal Adiposity Correlates with Adenotonsillectomy Outcome in Obese Adolescents with Severe Obstructive Sleep Apnea

1Penn State Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, PA, USA
2Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, USA
3Division of Pediatric Pulmonary and Sleep Medicine, Penn State Hershey Children's Hospital, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA
4Division of Allergy and Immunology, Pennsylvania State University College of Medicine, Hershey, PA, USA
5Department of Electronics Engineering, Javeriana University, Bogota, Colombia
6Department of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia
7Department of Pediatric Pulmonology and Pediatric Critical Care Medicine, School of Medicine, Universidad El Bosque, Bogota, Colombia
8Research Unit, Military Hospital of Colombia, Bogota, Colombia

Received 8 June 2012; Accepted 15 October 2012

Academic Editor: Graham Roberts

Copyright © 2012 Gustavo Nino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Obese adolescents with Obstructive Sleep Apnea (OSA) have a unique pathophysiology that combines adenotonsillar hypertrophy and increased visceral fat distribution. We hypothesized that in this population waist circumference (WC), as a clinical marker of abdominal fat distribution, correlates with the likelihood of response to AT. Methods. We conducted a retrospective cohort study of obese adolescents ( percentile) that underwent AT for therapy of severe OSA ( ). We contrasted WC and covariates in a group of subjects that had complete resolution of severe OSA after AT ( ) with those obtained in subjects with residual OSA after AT ( ). Multivariate linear and logistic models were built to control possible confounders. Results. WC correlated negatively with a positive AT response in young adolescents and the percentage of improvement in obstructive apnea-hypopnea index (OAHI) after AT ( ). Extended multivariate analysis demonstrated that the link between WC and AT response was independent of demographic variables, OSA severity, clinical upper airway assessment, obesity severity (BMI), and neck circumference (NC). Conclusion. The results suggest that in obese adolescents, abdominal fat distribution determined by WC may be a useful clinical predictor for residual OSA after AT.