Study Year
Criteria Treatment Findings Hu et al. [6 ] 2006 84 Solitary brain metastasis SRS or surgery Stage I intrathoracic patients had better OS outcomes than stage III Bonnette et al. [7 ] 2001 108 Brain metastasis (98 with solitary) Surgery Adenocarcinoma, T stage, complete resection with better outcomes Rodrigues et al. [8 ]
2011 66 ≤6 intracranial lesions Image-guided SIB RT Presence of systemic disease, lower performance status correlated with decreased OS Iwasaki et al. [9 ] 2004 41 Solitary brain metastasis Resection of primary site and brain metastasis Risk score criteria for improved OS: Mussi et al. [10 ] 1996 52 Solitary brain metastasis Resection of primary site and brain metastasis No status, lobectomy associated with decreased OS. 5-year OS in patients with synchronous/metachronous lesions 6.6/19%, respectively
Machiarini et al.[11 ] 1991 37 Solitary brain metastasis. Synchronous (<1 month) and metachronous included. Resection of primary site and brain metastasis Most frequent site of first recurrence was ipsilateral thorax (
) and brain (
). The receipt of adjuvant chemotherapy was strongest predictor of disease-free interval Wronski et al. [12 ] 1995 231 Single (87%) or multiple (13%) metastatic intracranial lesions Resection Female gender, complete location, infratentorial location, no systemic metastases, age < 60 years associated with improved OS
