A Call for the Aggressive Treatment of Oligometastatic and Oligo-Recurrent Non-Small Cell Lung Cancer

Table 1

Selected series for the comprehensive treatment of metastatic NSCLC.

Study	𝑁	Metastatic sites	Treatments	1-year PFS	5-year OS
University of Maryland [23]	72	Brain (metachronous)	SRS		13.2%
University of Maryland [24]	42	Brain (synchronous)	SRS, TS, RT, CRT, HIGRT		21%
Hopital Louis Pradel; Hospices Civils de Lyon, Lyonnce [25]	51	Brain (synchronous)	BS, TS, RT, CRT		42% (BS + others) versus 5% (BS only)*
University of Rochester [26]	38	Multisite, 1–8 metastases	HIGRT		14%
Rush University Medical Center [27]	23	Multi-site, 1-2 metastases	TS, RT, HIGRT		22%
University of Chicago [28]	25	Multi-site, 1–5 metastases	HIGRT (3–10 fx)	28%	53% (18 mo)
Maastricht University Medical Center [29]	39	Brain, bone, adrenal	TS, SRS, RT, HIGRT		24%*

*2 yr estimates; SRS: stereotactic radiosurgery; BS: brain surgery; TS: thoracic Surgery; RT: radiotherapy; CRT: chemoradiotherapy; HIGRT: hypofractionated image-guided radiotherapy.